Endothelin-2 is a Hypoxia-induced Autocrine Survival Factor for Breast Tumor Cells. The synthesis of EDN2 by human kidney carcinoma cells is decreased by EGF. EDN2 is a chemoattractant for macrophages and THP-1 monocytic cells. Chemotaxis towards EDN2 is via the MAPK pathway: p44 and p42 are phosphorylated when THP-1 cells are stimulated with EDN2. Migration to EDN2 is inhibited by hypoxia and by pertussis toxin. EDN2 leads to activation of macrophages. EDN2 shares a similar peptide sequence with chemokines and may signal via a similar receptor and MAPK-mediated pathway. Furthermore, EDN2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.
18.3 & 35.7 kDa, under reducing conditions; 21.3 & 35.3 & 51.6 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 0.4M Urea, 10% Glycerol, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Endothelin-2/ET-2 Protein (rp192066) - SDS-PAGE 3 μg/lane of Recombinant Human Endothelin-2/ET-2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 18.3 & 35.7 kDa under reducing conditions and 21.3 & 35.3 & 51.6 kDa under non-reducing conditions. Endothelin-2 (ET-2) is a small peptide that structurally resembles other endothelins (such as Endothelin-1 and Endothelin-3). ET-2 typically acts as a monomer inside cells. However, studies suggest that endothelin-like proteins may form dimers or multimers under certain conditions (PMID: 22874467).
ZJ25F0420323
危险品化学品经营许可证（带存储）