C20orf11 | Chromosome 20 open reading frame 11 | CT011_HUMAN | GID complex subunit 8 homolog | Glucose induced degradation protein 8 homolog | Protein C20orf11 | Twa1 | Two hybrid associated protein 1 | Two hybrid associated protein 1 with RanBPM | Two hy
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),See COA
生化机理
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).
Post-translational: Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation.
27.1 kDa, under reducing conditions; 27.4 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
PBS, 1mM DTT, 20% Glycerol, pH 7.4
浓度
See COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human GID8 Protein (rp192109) - SDS-PAGE 3 μg/lane of Recombinant Human GID8 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 27.1 kDa under reducing conditions and 27.4 kDa under non-reducing conditions.
ZJ25F0826314
危险品化学品经营许可证（带存储）