GIMAP6 is a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is found in a cluster with seven additional GIMAP genes on the long arm of chromosome 7.
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Recombinant Human GIMAP6 Protein (rp192111) - SDS-PAGE 2 μg/lane of Recombinant Human GIMAP6 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 36.6 & 75.4 kDa under reducing conditions and 37.6 & 75.5 kDa under non-reducing conditions.
GTPase activity in the GIMAP family is controlled by homo and heterodimerization. (PMID: 23454188)