C19ORF3 | Chromosome 19 open reading frame 3 | GAIP C-terminus-interacting protein | GIPC | GIPC PDZ domain containing family member 1 | GIPC1 | GIPC1_HUMAN | GLUT1 C terminal binding protein | GLUT1CBP | Hs.6454 | IGF 1 receptor interacting protein 1 | I
规格或纯度
无载体, ≥95%(SDS-PAGE), 见COA
生化机理
GIPC1 is a PDZ domain protein that cooperates with RGS-GAIP and the viral oncoprotein TAX, which transactivates viral and cellular promoters throughout interactions with different transcription factors. GIPC1 particularly localizes to clusters of vesicles close to the plasma membrane and takes part in G protein-coupled signaling pathway participating in regulating Clathrin-coated vesicular trafficking. GIPC1 cooperates with membrane bound Semaphorin F, which is takes part in neuronal axon growth, and controls the subcellular distribution of M-SemF in the brain.
Store at -20℃ for 12 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant Human GIPC1 Protein (rp192112) - SDS-PAGE 3 μg/lane of Recombinant Human GIPC1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 38.2 kDa under reducing conditions and 36.2 & 39.4 kDa under non-reducing conditions. GIPC1 is a scaffolding protein involved in various cellular processes, which has a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain. Multiple conformations may be formed through local conformational adjustments, ligand-induced allosterism, and post-translational modifications, so as to adapt to their multifunctional scaffold roles (PMID:9770488).
ZJ25F0927528
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