Beta subunit signal transducing proteins GS/GI | G protein beta 1 subunit | GBB1 | GBB1_HUMAN | gnb1 | Guanine nucleotide binding protein (G protein) beta polypeptide 1 | Guanine nucleotide binding protein beta 1 subunit | Guanine nucleotide-binding prote
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥80%(SDS-PAGE),见COA
生化机理
Heterotrimeric guanine nucleotide-binding proteins (G proteins) which integrate signals between receptors and effector proteins, are comprised of an alpha, a beta and a gamma subunit. The alpha, beta and gamma subunits are encoded by families of related genes. GNB1 encodes a beta subunit. Beta subunits are vital regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. G proteins are involved as a modulator or transducer in numerous transmembrane signaling systems. The beta and gamma chains are necessary for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Post-translational: Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.
生物活性
Immobilized Recombinant Human GNB1 Protein (rp192116) at 1.0 μg/mL can bind GNB1 Antibody (Ab105938) with the EC50 of 16.9 ng/mL.
34.7 kDa, under reducing conditions; 33.9 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 0.4M Urea, 10% Glycerol, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human GNB1 Protein (rp192116) - ELISA Immobilized Recombinant Human GNB1 Protein (rp192116) at 1.0 μg/mL can bind GNB1 Antibody (Ab105938) with the EC₅₀ of 16.9 ng/mL.
Recombinant Human GNB1 Protein (rp192116) - SDS-PAGE 3 μg/lane of Recombinant Human GNB1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 34.7 kDa under reducing conditions and 33.9 kDa under non-reducing conditions.