级别和纯度: 无载体?无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。His标签?组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。≥90%(SDS-PAGE)expressed in E. coli, 见 COA
无载体,His标签,≥90%(SDS-PAGE),expressed in E. coli, 见 COA
生化机理
Estradiol 17-beta-dehydrogenase 1, also known as HSD17B1, belongs to a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This protein is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants.
Recombinant Human HSD17B1 Protein (rp192126) - SDS-PAGE
3 μg/lane of Recombinant Human HSD17B1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 35.3 kDa under reducing conditions and 31.6-35.4 kDa under non-reducing conditions.
HSD17B1, also known as 17-beta-hydroxysteroid dehydrogenase type 1, is highly likely to exhibit multiple closely spaced bands during prokaryotic expression under non-reducing conditions (Uniprot ID: P14061).
ZJ26F0333182
危险品化学品经营许可证（带存储）