PSMB1 is part of the proteasome B-type family, also identified as the T1B family, that is a 20S core beta subunit. PSMB1 is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.The main function of PSMB1 is its degradation activity of unnecessary or damaged proteins by proteolysis. PSMB1 is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
24.1 kDa, under reducing conditions; 21.1 & 25.4 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 1mM DTT, 5% Glycerol, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃（6个月）；收货后建议分装，避免反复冻融。
图片
Recombinant Human PSMB1 Protein (rp192160) - SDS-PAGE
3 μg/lane of Recombinant Human PSMB1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the bands at 24.1 kDa under reducing conditions and 21.1 & 25.4 kDa under non-reducing conditions.
PSMB1 is a non-catalytic component of the 20S core proteasome complex, involved in the proteolytic degradation of the majority of intracellular proteins, and may exist in multiple conformations (PMID: 25599644).
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