GTP-binding protein SAR1a | COPII-associated small GTPase | SAR1A | SAR1 | SARA | SARA1
规格或纯度
无载体,His标签,≥85%(SDS-PAGE),见COA
生化机理
SAR1A is a member of the small GTPase superfamily. SAR1A is a vital component of COPII vesicle coats involved in export of cargo from the ER (Endoplasmic Reticulum). The GTPase activity of SAR1A serves as a molecular switch to control protein-protein and protein-lipid interactions which dictate vesicle budding from the ER. SAR1A, while GDP-bound interacts with the membrane-bound exchange factor Sec12 and trades its bound GDP for GTP. SAR1A is also involved in the transport from the ER to the Golgi apparatus. SAR1A is required to maintain SEC16A localization at distinct locations on the ER membrane possibly by preventing its dissociation. SAR1A-GTP-dependent compilation of SEC16A on the ER membrane creates a structured scaffold defining endoplasmic reticulum exit sites.
22.9 kDa, under reducing conditions; 19.7 & 24.6 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 1mM DTT, 10% Glycerol, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 存储6个月；收货后建议分装，避免反复冻融。
图片
Recombinant Human SAR1A Protein (rp192230) - SDS-PAGE 3 μg/lane of Recombinant Human SAR1A Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 22.9 kDa under reducing conditions and 19.7 & 24.6 kDa under non-reducing conditions. SAR1A is a GTPase that may produce multiple isoforms in the context of its physiological function(PMID: 32358066).
危险品化学品经营许可证（带存储）