CYC | CYC_HUMAN | CYCS | Cytochrome c | Cytochrome c somatic | HCS | THC4
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),见COA
生化机理
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Post-translational: Binds 1 heme c group covalently per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Cytochrome c Protein (rp214398) - SDS-PAGE 3 μg/lane of Recombinant Human Cytochrome c Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 14.0 & 27.3 kDa. Cytochrome c is a high-spin haem protein that forms a dimeric structure (PMID: 6250058).
ZJ25F0420906
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