CAP1 | DJ-1 | DJ1 | DJ1 protein | Epididymis secretory sperm binding protein Li 67p | FLJ27376 | FLJ34360 | FLJ92274 | HEL S 67p | Oncogene DJ1 | OTTHUMP00000001348 | OTTHUMP00000001349 | OTTHUMP00000001350 | OTTHUMP00000001351 | PARK7 | PARK7_HUMAN | Par
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥95%(SDS-PAGE),见COA
生化机理
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.
Post-translational: Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for cell-growth promoting activity and transforming activity. Cys-106 is easily oxidized to sulfinic acid. Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress.
生物活性
Immobilized Recombinant Human PARK7 Protein (rp214401) at 1.0 μg/mL can bind PARK7 Antibody (Ab120346) with the EC50 of 13.9 ng/mL.
Store at -20℃ for 6 months.Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant Human PARK7 Protein (rp214401) - ELISA Immobilized Recombinant Human PARK7 Protein (rp214401) at 1.0 μg/mL can bind PARK7 Antibody (Ab120346) with the EC₅₀ of 13.9 ng/mL.
Recombinant Human PARK7 Protein (rp214401) - SDS-PAGE 3 μg/lane of Recombinant Human PARK7 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 23.3 kDa under reducing conditions and 21.6 kDa under non-reducing conditions.
ZJ25F0622686
危险品化学品经营许可证（带存储）