Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
Post-translational: May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Recombinant Human p63 Protein (rp214418) - SDS-PAGE 3 μg/lane of Recombinant Human p63 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 31.8 kDa under reducing conditions and 31.1 & 76.2 & 131.9 kDa under non-reducing conditions. Tumor protein p63 binds DNA as a homotetramer, and the specific combination of isoforms within this tetramer can influence its transactivation activity (PMID: 10373484).
ZJ25F0623056
危险品化学品经营许可证（带存储）