14-3-3 alpha | 14-3-3 protein beta/alpha | 1433B_HUMAN | Brain protein 14-3-3 beta isoform | GW128 | HS 1 | KCIP-1 | KCIP1 | N-terminally processed | Protein 1054 | Protein kinase C inhibitor protein 1 | YWHAA | YWHAB
规格或纯度
无载体,His标签,≥90%(SDS-PAGE),见COA
生化机理
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Post-translational: The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
27.9 kDa, under reducing conditions; 27.5 & 28.1 & 54.3 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
PBS, 5% Glycerol, pH 7.4
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 储存 12个月；收货后建议分装，避免反复冻融。
图片
Recombinant Human 14-3-3 beta/alpha Protein (rp214462) - SDS-PAGE 2 μg/lane of Recombinant Human 14-3-3 beta/alpha Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 27.9 kDa under reducing conditions and 27.5 & 28.1 & 54.3 kDa under non-reducing conditions. 14-3-3 beta/alpha can form homodimer (Uniptot: P31946). Under non-reducing conditions, the cysteine residues of YWHAB form different disulfide bonds (Cys12-Cys214 or Cys26-Cys189), leading to structural domain rearrangements that enable the protein to adopt two distinct conformations (PMID: 15347690).
ZJ25F0622893
危险品化学品经营许可证（带存储）