AIP1 | ALG 2 interacting protein 1 | ALG-2-interacting protein 1 | ALG2 interacting protein X | Alix | Apoptosis linked gene 2 interacting protein X | Dopamine receptor interacting protein 4 | DRIP4 | Hp95 | KIAA1375 | MGC17003 | PDC6I_HUMAN | PDCD6 inter
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),见COA
生化机理
Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.
Post-translational: May be phosphorylated on tyrosine residues by activated PDGFRB.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存1年；复溶后建议分装，避免反复冻融。
图片
Recombinant Human ALIX Protein (rp214499) - SDS-PAGE 3 μg/lane of Recombinant Human ALIX Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 17.2 kDa under reducing conditions and 17.8 & 37.4 kDa under non-reducing conditions. Dimeric ALIX represents the active form that interacts with ESCRT-III CHMP4 polymers and functions as a scaffolding protein during membrane remodeling processes (PMID: 19523902).
ZJ25F0622456
危险品化学品经营许可证（带存储）