无动物源,无载体,Fc标签,≥95%(SDS-PAGE),expressed in HEK293; 见COA
生化机理
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells.Required for early embryonic development (By similarity).Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor.Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread.May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Also acts as a receptor for IGFBP3 to mediate cell growth inhibition.(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Post-translational: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.The N-terminus is blocked.Phosphorylated on serine and threonine residues.Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
74.8-86.1 kDa, under reducing conditions; 129.1-154.2 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
expressed in HEK293; 见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 6个月；复溶后建议分装，避免反复冻融。
图片
Recombinant Human LRP-1 Protein (rp217150) - SDS-PAGE
2 μg/lane of Recombinant Human LRP-1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 74.8-86.1 kDa under reducing conditions and 129.1-154.2 kDa under non-reducing conditions.
Fc fusion proteins can be linked by disulfide bonds in the Fc hinge region to form stable dimers (PMID: 23665380).
危险品化学品经营许可证（带存储）