Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
Post-translational: Sulfation on Tyr-1699 is essential for binding vWF. Proteolytically cleaved by cathepsin CTSG to produce a partially activated form.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12 个月；复溶后建议分装，避免反复冻融。
图片
Recombinant Human Factor VIII Protein (rp217155) - SDS-PAGE 2 μg/lane of Recombinant Human Factor VIII Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 25.1 kDa under reducing conditions and 25.2 & 44.8 kDa under non-reducing conditions. Factor VIII, a non-covalent heterodimer comprised of a heavy chain (A1-A2-B domains) and light chain (A3-C1-C2 domains), circulates as an inactive procofactor in complex with von Willebrand factor (PMID: 16513527).
ZJ26F0636049
危险品化学品经营许可证（带存储）