Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
19.1 kDa, under reducing conditions; 18.2 & 36.5 & 55.8 kDa, under non-reducing conditions.
分子类型
蛋白质
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 20mM Tris, 500mM NaCl, 8M Urea, 108 mM Imidazole, pH 8.0
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12个月；复溶后建议分装，避免反复冻融。
图片
Recombinant Human EMR1 Protein (rp218438) - SDS-PAGE 2 μg/lane of Recombinant Human EMR1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 19.1 kDa under reducing conditions and 18.2 & 36.5 & 55.8 kDa under non-reducing conditions. The GAIN-B domain and GPS orchestrate the activity of EMR1/ADGRE1 via a dual mechanism: stabilizing a self-inhibited conformation (resting state) to suppress basal signaling and enabling ligand- or force-dependent conformational transitions (activated state) to initiate downstream pathways (PMID: 34282836; PMID: 7601460).
ZJ25F0927840
危险品化学品经营许可证（带存储）