The alkali resistant recombinant protein A produced by our company is expressed in a prokaryotic system, separated and purified, and has a molecular weight of approximately 29 kDa. This protein product has a His6 tag sequence at the N-terminus.
规格
产品名称
重组耐碱蛋白A
英文别名
Recombinant Protein A | Protein A | Staphylococcal Protein A | Staphylococcal Protein A Recombinant | Immunoglobulin G-binding protein A | gG-binding protein A | Immunoglobulin G binding protein A | SPA | rat-PA
规格或纯度
无动物源,无载体,His标签,≥90%(SDS-PAGE),见COA
生化机理
Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. Acts directly as a pro-inflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A (By similarity).
表达系统
E. coli
种属
金黄色葡萄球菌(Staphylococcus aureus)
蛋白标签
N-His
无载体
Yes
无动物源
Yes
来源
重组表达
预测分子量
29 kDa
SDS-PAGE
29 kDa
CAS编号和信息
91932-65-9
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20 mM Tris.Cl, 0.2M NaCl, pH 8.5
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。
图片
Recombinant Alkali-tolerant Protein A (rp224197) - SDS-PAGE 2 μg/lane of Recombinant Alkali-tolerant Protein A was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 26.3 kDa.
ZJ25F0724862
危险品化学品经营许可证（带存储）