级别和纯度: 无载体?无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。His标签?组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。≥90%(SDS-PAGE)expressed in E. coli; 见COA
无载体, His标签, ≥90%(SDS-PAGE), expressed in E. coli; 见COA
生化机理
Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity).
Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity).
Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity).
Regulates voltage-gated sodium channel transport and function (PubMed:15282281, PubMed:33245860, PubMed:36696443).
May also play a role in MAPK signaling (By similarity).
Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).
Post-translational: May be phosphorylated.
28.8 kDa, under reducing conditions; 28.2 & 29.1 & 53.4 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM PB, 500mM NaCl, pH 7.4
浓度
expressed in E. coli; 见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12个月；复溶后建议分装，避免反复冻融。
图片
Recombinant Human FGF13/FHF2 Protein (rp229039) - SDS-PAGE
2 μg/lane of Recombinant Human FGF13/FHF2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the bands at 28.8 kDa under reducing conditions and 28.2 & 29.1 & 53.4 kDa under non-reducing conditions.
The dimerization of FGF13 is mediated by its C-terminal domain and is the core mechanism by which it regulates the function of sodium channels in neurons. Under non-reducing conditions, the two bands may correspond to two conformations, mainly due to the formation of different disulfide bond pairs (conformational isomers) of the cysteine residues within their molecules (PMID: 39332965).
危险品化学品经营许可证（带存储）