72 kDa type IV collagenase | 72 kDa gelatinase | Gelatinase A | Matrix metalloproteinase-2 | MMP-2 | TBE-1 | MMP2 | CLG4A | CLG4 | MONA | MMP-II
规格或纯度
无动物源,无载体,His标签,≥90%(SDS-PAGE),expressed in HEK293; 见COA
生化机理
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity). Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
Post-translational: Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro (By similarity). The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3) (By similarity). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3 (By similarity).
72.5 kDa; under reducing conditions; 56.9 & 60.6 - 68.9 kDa; under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
PBS, 15% Glycerol, pH 7.4
浓度
expressed in HEK293; 见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 存储12个月；收货后建议分装，避免反复冻融。
图片
Recombinant Mouse MMP-2 Protein (rp231178) - SDS-PAGE
3 μg/lane of Recombinant Mouse MMP-2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 72.5 kDa under reducing conditions and 56.9 & 60.6 - 68.9 kDa under non-reducing conditions.
ZJ26F0435031
危险品化学品经营许可证（带存储）