His标签,无载体 级 提供 ≥90%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
IMPDH2 (inosine monophosphate dehydrogenase) is one of two cytosolic and nuclear enzyme isoforms that play a central role in guanine nucleotide metabolism. The isoforms are 84% identical but distinctly regulated. While IMPDH1 is generally constitutively expressed, IMPDH2 is inducible during proliferation and transformation. Both isoforms form a homotetramer of approximately 55 kDa monomers containing a catalytic barrel domain and a subdomain with two cystathione beta-synthase domains which mediate RNA and DNA binding. Both enzymes catalyze the NAD-dependent conversion of inosine monophosphate (IMP) to hypoxanthine monophosphate (XMP) which is a precursor for the synthesis of GMP, guanosine, and guanine. These compounds are critical for DNA synthesis and cell proliferation which explains the importance of IMPDH in cancer and viral infection. Although IMPDH1 and IMPDH2 are known to be inhibited by the immunosuppressant drug mycophenolic acid (MPA), much research has targeted discovery of additional and selective inhibitors for IMPDH isoforms given they are targets for several major therapeutic areas. Human IMPDH2 shares 99% amino acid sequence identity with mouse IMPDH2.
Post-translational: Ubiquitinated leading to its degradation by the proteasome.The N-terminus is blocked.Acetylated by CLOCK in a circadian manner (PubMed:28985504).
Recombinant Human IMP Dehydrogenase 2/IMPDH2 Protein (rp231843) - SDS-PAGE
3 μg/lane of Recombinant Human IMP Dehydrogenase 2/IMPDH2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 53.2 kDa under reducing conditions and 52.2 kDa under non-reducing conditions.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ25F0927550 |
分析证书 | rp231843 |
| ZJ25F0927551 |
分析证书 | rp231843 |
| ZJ25F0927552 |
分析证书 | rp231843 |
| ZJ25F0927553 |
分析证书 | rp231843 |
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