CIS3 | SSI3 | SOCS3 | Suppressor of cytokine signaling 3 | SOCS-3, Cytokine-inducible SH2 protein 3 | STAT-induced STAT inhibitor 3 | CIS-3 | SSI-3
规格或纯度
无动物源, 无载体, His标签, ≥90%(SDS-PAGE)
生化机理
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits signal transduction by binding to transmembrane signaling receptors including IL6ST/gp130, LIFR, EPOR, INSR, IL12RB2, CSF3R/G-CSF-R and LEPR. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Upon OSM stimulation, negatively regulates the JAK-STAT signaling mediated through type II OSM receptor complex by interacting directly with JAK1.
Post-translational: Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.