磺胺嘧啶钠盐(SD-Na), 细菌二氢蝶酸合成酶抑制剂

CAS: 547-32-0 货号: S107129 分子式: C10H9N4NaO2S 分子量: 272.26 Beilstein号: 4068213 EC号: 208-919-0 PubChem CID: 15899898
有货
级别和纯度: ≥98%
别名
磺胺嘧啶钠 | SPS 琼脂添加剂 | 4-氨基-N-(2-嘧啶基)苯磺酰胺 钠盐
储存条件
室温
运输条件
常规运输
★
规格
库存
价格
数量
5g
S107129-5g
现货 Stock Image
¥34.90
25g
S107129-25g
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¥80.90
100g
S107129-100g
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¥244.90
500g
S107129-500g
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¥736.90
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为什么选择此级别

提供 ≥98% 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

室温。常规运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 57 篇同行评审文献引用。

概述

无臭,味微苦;遇光色渐变暗;易溶于水,微溶于乙醇,水溶液遇酚酞指示液显碱性反应。


用途

磺胺嘧啶可作为内标物,用于通过高效液相色谱(HPLC)技术测定生物样品中的磺胺吡啶。

Application

Sulfadiazine may be used as an internal standard for the determination of sulfapyridine in biological samples using high-performance liquid chromatography technique.

规格

别名
磺胺嘧啶钠 | SPS 琼脂添加剂 | 4-氨基-N-(2-嘧啶基)苯磺酰胺 钠盐
英文别名
Sodium sulfapyrimidine | ()-MonoPhos | sodium;4-amino-N-pyrimidin-2-ylbenzenesulfonamide | N(sup 1)-2-Pyrimidinylsulfanilamide monosodium salt | Sulfadiazinum natricum (INN-Latin) | Solfadiazina sodica [DCIT] | s4634 | SPS Agar Supplement | Sulfadiazine s
规格或纯度
≥98%
英文名称
Sulfadiazine sodium salt
储存条件
室温
运输条件
常规运输
作用类型
抑制剂
作用机制
细菌二氢蝶酸合成酶抑制剂
纯度
≥98%
名称和识别符
PubChem SID
EC号
208-919-0
分子类型
小分子
IUPAC Name
sodium;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide
INCHI
1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
InChi Key
JLDCNMJPBBKAHH-UHFFFAOYSA-N
Smiles
C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Na+]
Isomeric SMILES
C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Na+]
PubChem CID
分子量
272.26
Beilstein号
4068213

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

系统学分类

分类树(Taxonomy Tree)

界(kingdom) 有机化合物
超类(Superclass) 苯类化合物
类(Class) 苯及其取代衍生物
亚类(Subclass) 苯磺酰胺类
中间层级节点(Intermediate Tree Nodes) 暂无
直接上位类(Direct Parent) 苯磺酰胺类
其他上位类(Alternative Parents) 苯磺酰基化合物  苯胺和取代苯胺  嘧啶和嘧啶衍生物  磺酰基  有机磺酸及其衍生物  杂芳族化合物  氮杂环化合物  伯胺  有机光子化合物  有机两性离子  有机钠盐  有机氧化物  碳氢化合物衍生物  
分子骨架(Molecular Framework) 芳香族杂单环化合物
取代基(Substituents) 氨基酸 - 苯胺或取代苯胺 - 芳香族杂单环化合物 - 氮杂环 - 苯磺酰胺 - 苯磺酰基 - 杂芳香族化合物 - 烃衍生物 - 有机碱金属盐 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机盐 - 有机钠盐 - 有机磺酸或其衍生物 - 有机双性离子 - 有机杂环化合物 - 有机氮化合物 - 有机氮化合物 - 有机磺酸或其衍生物 - 有机硫化合物 - 初级胺 - 嘧啶 - 磺酰基
描述(Description) 该化合物属于苯磺酰胺类有机化合物。这类化合物含有通过硫键连接至苯环的磺酰胺基团。
外部描述符(External Descriptors) 暂无
三维结构
交互式化学结构模型





化学和物理性质
密度
1.496
分子量
272.260 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
6
可旋转键计数Rotatable Bond Count
3
精确质量Exact Mass
272.034 Da
单同位素质量Monoisotopic Mass
272.034 Da
拓扑极表面积Topological Polar Surface Area
95.300 Ų
重原子数Heavy Atom Count
18
形式电荷Formal Charge
0
复杂度Complexity
332.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
2
安全和危险性(GHS)
象形图
GHS07,   GHS08
信号词
危险
危险声明

H302: 吞食有害

H315: 引起皮肤刺激

H317: 可能引起皮肤过敏反应

H319: 引起严重眼睛刺激

H334: 吸入可能引起过敏或哮喘病症状或呼吸困难

H335: 可能引起呼吸道刺激

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

P342+P311: 如有呼吸系统病症:呼叫急救中心/医生。

WGK Germany
3
RTECS
WP2000000
个人防护装备
dust mask type N95 (US),Eyeshields,Faceshields,Gloves
质检证书(CoA,COO,BSE/TSE 和分析图谱)
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批号(Lot Number) 证书类型 货号
J2218126 分析证书 S107129
J2218128 分析证书 S107129
J2218144 分析证书 S107129
J2218145 分析证书 S107129
K2109701 分析证书 S107129
D2509067 分析证书 S107129
F2604010 分析证书 S107129
K2514069 分析证书 S107129
此产品的引用文献
引用文献
1. Huang Jialu, Zhang Shuchi, Tan Mengyu, Shen Jie, Zhao Haiyan, Wu Donglei.  (2023)  Occurrence, removal, and risk assessment of emerging contaminants in aquatic products processing sewage treatment plants.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  [PMID:37874520] [10.1007/s11356-023-30458-z]
2. Wenming Yang, Mingyue Kuai, Changchun Wu, Wenqi Yang, Lingling Cao, Yi Zhang, Ting Chen, Yunfei Cao, Baozhi Wang, Wanzhen Xu.  (2023)  Dual-emission ratiometric fluorescence sensors based on silica, molecularly imprinted polymers and carbon quantum dots for high-sensitivity and high-selectivity detection of sulfadiazine.  POLYMER INTERNATIONAL,  [10.1002/pi.6578]
3. Jingyang Luo, Zhicheng Wei, Xiaoshi Cheng, Xinyi Liu, Feng Wang, Wenxuan Huang, Shiyu Fang, Junfeng Wu, Yang Wu, Jianchao Liu, Le Zhang.  (2023)  Surfactant and antibiotic co-occurrence reshaped the acidogenic process for volatile fatty acids production during sludge anaerobic fermentation.  SCIENCE OF THE TOTAL ENVIRONMENT,  [PMID:37714358] [10.1016/j.scitotenv.2023.167064]
4. Jing Dai, Ziqian Wang, Aoxue Zhu, Yuefei Ji, Zhe Kong, Tianming Cai, Dahu Ding.  (2023)  Elimination of sulfadiazine and its metabolite from hydrolyzed urine by biochar activated periodate process: Lower environmental risk compared with CoFe2O4/peroxymonosulfate process.  CHEMICAL ENGINEERING JOURNAL,  [10.1016/j.cej.2023.145080]
5. Weiping Chen, Bingzheng Wang, Yaqing Wang, Ji Li.  (2023)  Understanding the cometabolic degradation of sulfadiazine by an enriched ammonia oxidizing bacteria culture from both extracellular and intracellular perspectives.  CHEMOSPHERE,  [PMID:37330061] [10.1016/j.chemosphere.2023.139244]
6. Xuan Zhou, Jiaxin Li, Yuda Hu, Yaohui Wu, Yonghong Wang, Ge Ning.  (2023)  A novel colorimetric assay for sensitive detection of kanamycin based on the aptamer-regulated peroxidase-mimicking activity of Co3O4 nanoparticles.  Analytical Methods,  [PMID:37157837] [10.1039/D3AY00304C]
7. Yuchen Wang, Mengqin Li, Liangyu Zhu, Yanmei Wang.  (2023)  On-line preconcentration and determination of sulfadiazine in food samples using surface molecularly imprinted polymer coating by capillary electrophoresis.  JOURNAL OF CHROMATOGRAPHY A,  [PMID:37059046] [10.1016/j.chroma.2023.463965]
8. Yuan Liu, Zhen Tao, Hailong Lu, Siyi Li, Chao Hu, Zhongyang Li.  (2023)  Electrochemical properties of roots determine antibiotic adsorption on roots..  Frontiers in Plant Science,  [PMID:37152177] [10.3389/fpls.2023.930632]
9. Jingxuan Yang, Dongxu Qu, Jue Wang, Yangtao Wu, Lingjun Bu, Yuanxi Huang, Shiqing Zhou.  (2023)  UV-induced degradation of contaminants of emerging concern in the presence of monobromoamine: Role of N-Br bond and degradation mechanisms.  Journal of Environmental Chemical Engineering,  [10.1016/j.jece.2023.109646]
10. Feng Wang, Le Zhang, Yuting Luo, Yi Li, Xiaoshi Cheng, Jiashun Cao, Junfeng Wu, Haining Huang, Jingyang Luo, Yinglong Su.  (2023)  Surfactant aggravated the antibiotic's stress on antibiotic resistance genes proliferation by altering antibiotic solubilization and microbial traits in sludge anaerobic fermentation.  SCIENCE OF THE TOTAL ENVIRONMENT,  [PMID:36842577] [10.1016/j.scitotenv.2023.162440]
11. Chao Liu, Zhenxiang Chen, Ruiqin Kang, Jing Wang, Qingwei Lu, Tao Wang, Dayong Tian, Ying Xu, Zhan Wang, Huiping Ding.  (2023)  N-Rich Algal Sludge Biochar for Peroxymonosulfate Activation toward Sulfadiazine Removal.  Coatings,  13  (2): (431).  [10.3390/coatings13020431]
12. Xiao-lei Wang, Qi Wang, Ya-xian Xue, Bing Zhang, Shu-rui Han, Huan Zhang, Kong-yin Zhao, Wan Wang, Jun-fu Wei.  (2023)  Preparation of composite nanofiltration membrane with interlayer for pharmaceutical rejection.  SEPARATION AND PURIFICATION TECHNOLOGY,  [10.1016/j.seppur.2023.123411]
13. Chen-Ting Zhu, Kai-Yuan Huang, Qing-Lin Zhou, Xiang-Ping Zhang, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen, Hamada A.A. Noreldeen.  (2022)  Multi-excitation wavelength of gold nanocluster-based fluorescence sensor array for sulfonamides discrimination.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  [PMID:36442343] [10.1016/j.saa.2022.122138]
14. Yan Yan, Xiangjuan Ma, Yijing Xia, Huajun Feng, Shengjue Liu, Cong He, Yangcheng Ding.  (2022)  Mechanism of highly efficient electrochemical degradation of antibiotic sulfadiazine using a layer-by-layer GNPs/PbO2 electrode.  ENVIRONMENTAL RESEARCH,  [PMID:36368374] [10.1016/j.envres.2022.114778]
15. Yanzhuo Zhang, Jing Zhao.  (2022)  Comparison of different S-doped biochar materials to activate peroxymonosulfate for efficient degradation of antibiotics.  CHEMOSPHERE,  [PMID:36126742] [10.1016/j.chemosphere.2022.136442]
16. Yan Wang, Tao Gan, Jingyu Xiu, Ganghua Liu, Haiming Zou.  (2022)  Degradation of sulfadiazine in aqueous media by peroxymonosulfate activated with biochar-supported ZnFe2O4 in combination with visible light in an internal loop-lift reactor.  RSC Advances,  12  (37): (24088-24100).  [PMID:36128526] [10.1039/D2RA04573G]
17. Lulan Yang, Xingyue Chen, Xu Wen, Jiaming Tang, Xiaoling Zheng, Jiaqi Li, Lingling Chen, Shuang Jiang, Tao Le.  (2022)  A label-free dual-modal aptasensor for colorimetric and fluorescent detection of sulfadiazine.  Journal of Materials Chemistry B,  10  (32): (6187-6193).  [PMID:35894788] [10.1039/D2TB01115H]
18. Fuwei Sun, Tianhu Chen, Ziyang Chu, Peixun Zhai, Haibo Liu, Qiang Wang, Xuehua Zou, Dong Chen.  (2022)  The synergistic effect of calcite and Cu2+ on the degradation of sulfadiazine via PDS activation: A role of Cu(Ⅲ).  WATER RESEARCH,  [PMID:35569277] [10.1016/j.watres.2022.118529]
19. Yuanxi Huang, Lingjun Bu, Yangtao Wu, Shumin Zhu, Shiqing Zhou, Zhou Shi, Dionysios D. Dionysiou.  (2022)  Degradation of contaminants of emerging concern in UV/Sodium percarbonate Process: Kinetic understanding of carbonate radical and energy consumption evaluation.  CHEMICAL ENGINEERING JOURNAL,  [10.1016/j.cej.2022.135995]
20. Zeng Xue-Yu, Wang Yu, Li Rong-Xin, Cao Hai-Lei, Li Ya-Feng, Lü Jian.  (2022)  Impacts of temperatures and phosphoric-acid modification to the physicochemical properties of biochar for excellent sulfadiazine adsorption.  Biochar,  4  (1): (1-14).  [10.1007/s42773-022-00143-4]
21. Yanzhuo Zhang, Shengxu Liang, Rui He, Jing Zhao, Jinghua Lv, Wei Kang, Jian Zhang.  (2022)  Enhanced adsorption and degradation of antibiotics by doping corncob biochar/PMS with heteroatoms at different preparation temperatures: Mechanism, pathway, and relative contribution of reactive oxygen species.  Journal of Water Process Engineering,  [10.1016/j.jwpe.2022.102626]
22. Xu Qiao, Yuhan Xia, Xuhan Su, Bingkun Wang, Guang Chen, Huan Chen.  (2022)  Preparation of biomass carbon material based on fulvic acid and its application in dye and antibiotic treatments.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  [10.1016/j.colsurfa.2022.128302]
23. Fuwei Sun, Haibo Liu, Ziyang Chu, Peixun Zhai, Tianhu Chen, Hanlin Wang, Xuehua Zou, Dong Chen.  (2021)  The effect of isomorphic substitution on siderite activation of hydrogen peroxide: The decomposition of H2O2 and the yield of ·OH.  CHEMICAL GEOLOGY,  [10.1016/j.chemgeo.2021.120555]
24. Yang Zong, Hua Zhang, Yufei Shao, Wenjie Ji, Yunqiao Zeng, Longqian Xu, Deli Wu.  (2021)  Surface-mediated periodate activation by nano zero-valent iron for the enhanced abatement of organic contaminants.  JOURNAL OF HAZARDOUS MATERIALS,  [PMID:34482081] [10.1016/j.jhazmat.2021.126991]
25. Fuwei Sun, Tianhu Chen, Haibo Liu, Xuehua Zou, Peixun Zhai, Ziyang Chu, Daobing Shu, Hanlin Wang, Dong Chen.  (2021)  The pH-dependent degradation of sulfadiazine using natural siderite activating PDS: The role of singlet oxygen.  SCIENCE OF THE TOTAL ENVIRONMENT,  [PMID:33895517] [10.1016/j.scitotenv.2021.147117]
26. Fuwei Sun, Tianhu Chen, Xuehua Zou, Haibo Liu, Ziyang Chu, Daobing Shu, Hanlin Wang, Fangju Huang, Dong Chen.  (2021)  A quantitative analysis of hydroxyl radical generation as H2O2 encounters siderite: Kinetics and effect of parameters.  APPLIED GEOCHEMISTRY,  [10.1016/j.apgeochem.2021.104893]
27. Xinxiang Geng, Siying Lv, Jing Yang, Shihai Cui, Zehua Zhao.  (2020)  Carboxyl-functionalized biochar derived from walnut shells with enhanced aqueous adsorption of sulfonamide antibiotics.  JOURNAL OF ENVIRONMENTAL MANAGEMENT,  [PMID:33309112] [10.1016/j.jenvman.2020.111749]
28. Xianglei He, Jialiang Li, Qingmei Meng, Ziyu Guo, Hao Zhang, Yurong Liu.  (2020)  Enhanced adsorption capacity of sulfadiazine on tea waste biochar from aqueous solutions by the two-step sintering method without corrosive activator.  Journal of Environmental Chemical Engineering,  [10.1016/j.jece.2020.104898]
29. K.M. Wang, J. Shu, S.J. Wang, T.Y. Hong, X.P. Xu, H.Y. Wang.  (2019)  Efficient electrochemical generation of ferrate(VI) by iron coil anode imposed with square alternating current and treatment of antibiotics.  JOURNAL OF HAZARDOUS MATERIALS,  [PMID:31676166] [10.1016/j.jhazmat.2019.121458]
30. Fan Zhang, Nan Ye, Se Wang, Yue Meng, Hao Fang, Zhuang Wang, De-Gao Wang.  (2019)  Dissolved Organic Matter Modulates Algal Oxidative Stress and Membrane System Responses to Binary Mixtures of Nano-Metal-Oxides (nCeO2, nMgO and nFe3O4) and Sulfadiazine.  Nanomaterials,  9  (5): (712).  [PMID:31067831] [10.3390/nano9050712]
31. Jing Xie, Xu Duan, Leiyu Feng, Yuanyuan Yan, Feng Wang, Haiqing Dong, Renyong Jia, Qi Zhou.  (2018)  Influence of sulfadiazine on anaerobic fermentation of waste activated sludge for volatile fatty acids production: Focusing on microbial responses.  CHEMOSPHERE,  [PMID:30543966] [10.1016/j.chemosphere.2018.12.015]
32. Guanglan Di, Zhiliang Zhu, Qinghui Huang, Hua Zhang, Jianyao Zhu, Yanling Qiu, Daqiang Yin, Jianfu Zhao.  (2018)  Targeted modulation of g-C3N4 photocatalytic performance for pharmaceutical pollutants in water using ZnFe-LDH derived mixed metal oxides: Structure-activity and mechanism.  SCIENCE OF THE TOTAL ENVIRONMENT,  [PMID:30308799] [10.1016/j.scitotenv.2018.09.134]
33. Tuqiao Zhang, Feilong Dong, Feng Luo, Cong Li.  (2018)  Degradation of sulfonamides and formation of trihalomethanes by chlorination after pre-oxidation with Fe(VI).  Journal of Environmental Sciences,  [PMID:30290875] [10.1016/j.jes.2018.01.016]
34. Xiuping He, Liju Tan, Wei Wu, Jiangtao Wang.  (2016)  Determination of sulfadiazine in eggs using molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography.  JOURNAL OF SEPARATION SCIENCE,  39  (11): (2204-2212).  [PMID:27063936] [10.1002/jssc.201600233]
35. Pengfei Ma, Zhiping Zhou, Wenming Yang, Bingqing Tang, Hong Liu, Wanzhen Xu, Weihong Huang.  (2014)  Preparation and application of sulfadiazine surface molecularly imprinted polymers with temperature-responsive properties.  JOURNAL OF APPLIED POLYMER SCIENCE,  132  (15): [10.1002/app.41769]
36. Shao-Peng Rong, Ya-Bing Sun, Ze-Hua Zhao.  (2013)  Degradation of sulfadiazine antibiotics by water falling film dielectric barrier discharge.  CHINESE CHEMICAL LETTERS,  [10.1016/j.cclet.2013.11.003]
37. Fang Yu, Chang Liu, Yuhong Guo, Yaling Yang.  (2013)  Ultrasound-assisted cloud point extraction for the determination of sulfonamides in honey samples by fluorescence spectrophotometry.  Analytical Methods,  5  (16): (3920-3926).  [10.1039/C3AY26587K]
38. Guohao Zhai, Yuxuan Ma, Huixian Liu, Hongtao Jia, Shanshan Wang, Shuai Liu.  (2024)  Adsorption of sulfadiazine from water by Pedicularis kansuensis derived biochar: Preparation and properties studies.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,  [10.1016/j.jiec.2024.09.007]
39. Jiale Xu, Yuting Zhang, Shaoxin Zi, Xuanqi Zhang, Zhengtong Qian, Jin Liu.  (2024)  Aging-mediated selective adsorption of antibiotics by tire wear particles: Hydrophobic and electrostatic interactions effects.  JOURNAL OF CONTAMINANT HYDROLOGY,  [PMID:39662238] [10.1016/j.jconhyd.2024.104482]
40. Zhi Mei, Fang Wang, Yuhao Fu, Yu Liu, Syed A. Hashsham, Yu Wang, Jean Damascene Harindintwali, Qingyuan Dou, Marko Virta, Xin Jiang, Yu Deng, Tong Zhang, James M. Tiedje.  (2024)  Biofilm enhanced the mitigations of antibiotics and resistome in sulfadiazine and trimethoprim co-contaminated soils.  JOURNAL OF HAZARDOUS MATERIALS,  [PMID:39255667] [10.1016/j.jhazmat.2024.135721]
41. Zhang Xuxin, Li Yihao, Xia Shaojie, Yang Zhenyuan, Zhang Baiyun, Wang Yonghong.  (2024)  Chemiluminescence detection of kanamycin by DNA aptamer regulating peroxidase-like activity of Co3O4 nanoparticles.  ANALYTICAL SCIENCES,  [PMID:39287726] [10.1007/s44211-024-00672-x]
42. Zhang Zekun, Zhao Le, Yang Jie, Pang Jiayin, Lambers Hans, He Honghua.  (2024)  Effects of environmentally relevant concentrations of oxytetracycline and sulfadiazine on the bacterial communities, antibiotic resistance genes, and functional genes are different between maize rhizosphere and bulk soil.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  [PMID:38409385] [10.1007/s11356-024-32578-6]
43. Yifei Leng, Ying Zhang, Xiong Chen, Ting He, Fengyi Chang, Zhu Li, Yu Huang, Jun Wang, Wen Xiong.  (2025)  Enhanced transformation of sulfadiazine by horseradish peroxidase activated persulfate progress: Characteristics, pathways, mechanisms, and ecotoxicities.  Journal of Environmental Chemical Engineering,  [10.1016/j.jece.2025.116140]
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