计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 16 篇同行评审文献引用。
概述
Sulfamethizole是磺胺噻唑类抗生素，能抑制细菌的PABA。
Sulfamethizole is a sulfathiazole antibacterial agent.
规格
别名
磺胺甲噻二唑 | 4-氨基-N-(5-甲基-1,3,4-噻二唑-2-基)苯磺酰胺 | N1-(5-甲基-1,3,4-噻二唑-2-基)磺胺
英文别名
HSDB 4379 | Solfametizolo [DCIT] | SULFAMETHIZOLE [HSDB] | KBioGR_001260 | Prestwick2_000742 | SULFAMETHIZOLE (EP IMPURITY) | SULFAMETHIZOLE (MART.) | VK 53 | CCRIS 756 | Urosulfin | HMS500H03 | Methazol | Microsul | Epitope ID:122233 | Solfametizolo | KB
规格或纯度
≥98%
英文名称
Sulfamethizole
应用
储存条件
2-8°C储存
运输条件
低温运输
作用类型
抑制剂
作用机制
细菌二氢蝶酸合成酶抑制剂
纯度
≥98%
名称和识别符
PubChem SID
EC号
205-641-1
分子类型
小分子
IUPAC Name
4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
INCHI
1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)
InChi Key
VACCAVUAMIDAGB-UHFFFAOYSA-N
Smiles
CC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES
CC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N
PubChem CID
分子量
270.33
Beilstein号
255002
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 苯类化合物 |
| 类（Class) | 苯及其取代衍生物 |
| 亚类（Subclass） | 苯磺酰胺类 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 氨基苯磺酰胺类 |
| 其他上位类（Alternative Parents） | 苯磺酰基化合物 苯胺和取代苯胺 有机磺酰胺 噻二唑类 杂芳族化合物 氨基磺酰基化合物 氮杂环化合物 伯胺 有机光子化合物 有机氧化物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 芳香族杂单环化合物 |
| 取代基（Substituents） | 氨基酸 - 氨基苯磺酰胺 - 氨基磺酰基化合物 - 苯胺或取代苯胺 - 芳香族杂单环化合物 - 氮杂环 - 吡唑 - 苯磺酰基 - 杂芳香族化合物 - 烃衍生物 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机磺酸或其衍生物 - 有机杂环化合物 - 有机氮化合物 - 有机氮化合物 - 有机硫酰胺 - 有机磺酸或其衍生物 - 有机硫化合物 - 初级胺 - 磺酰基 - 噻二唑 |
| 描述（Description） | 该化合物属于有机化合物中的氨基苯磺酰胺类。这类化合物含有苯磺酰胺结构单元，其苯环上连接有胺基。 |
| 外部描述符（External Descriptors） | sulfonamide - thiadiazoles - sulfonamide antibiotic |
三维结构
交互式化学结构模型
产品属性
| ALogP | 0.5 |
|---|
关联靶点（人）
PDE5A
Tclin
Phosphodiesterase 5A
(5113 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
HMGCR
Tclin
HMG-CoA reductase
(2475 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
INSR
Tclin
Insulin receptor
(5558 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
ACE
Tclin
Angiotensin-converting enzyme
(1423 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
GABRA1
Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
ADRA1D
Tclin
Alpha-1d adrenergic receptor
(4171 活性数据)
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor
(2801 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
AVPR2
Tclin
Vasopressin V2 receptor
(2912 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
AGTR1
Tclin
Type-1 angiotensin II receptor
(5176 活性数据)
CALCR
Tclin
Calcitonin receptor
(2215 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
ADRA1B
Tclin
Alpha-1b adrenergic receptor
(2912 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
HTR3A
Tclin
Serotonin 3a (5-HT3a) receptor
(3366 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
GRIN1
Tclin
Glutamate (NMDA) receptor subunit zeta 1
(122 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
HTR4
Tclin
Serotonin 4 (5-HT4) receptor
(2068 活性数据)
CACNA1C
Tclin
Voltage-gated L-type calcium channel alpha-1C subunit
(766 活性数据)
关联靶点（其它种属）
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 活性数据)
ampC
Beta-lactamase AmpC (62480 活性数据)
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Ltc4s
Leukotriene C4 synthase (1 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Pde4d
Phosphodiesterase 4D (4 活性数据)
Ppard
Peroxisome proliferator-activated receptor delta (358 活性数据)
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
folP
Dihydropteroate synthase (129 活性数据)
Klebsiella pneumoniae (43867 活性数据)
Escherichia coli (133304 活性数据)
Bacillus subtilis (32866 活性数据)
lef
Anthrax lethal factor (7585 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Akt1
RAC-alpha serine/threonine-protein kinase (147 活性数据)
Plasma (328 活性数据)
Glra2
Glycine receptor (1745 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
密度
1.562
敏感性
对光敏感
熔点
210°C
分子量
270.300 g/mol
XLogP3
0.500
氢键供体数Hydrogen Bond Donor Count
2
氢键受体数Hydrogen Bond Acceptor Count
7
可旋转键计数Rotatable Bond Count
3
精确质量Exact Mass
270.025 Da
单同位素质量Monoisotopic Mass
270.025 Da
拓扑极表面积Topological Polar Surface Area
135.000 Ų
重原子数Heavy Atom Count
17
形式电荷Formal Charge
0
复杂度Complexity
348.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H314: 造成严重的皮肤灼伤和眼睛损伤
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P272: 被污染的工作服不允许离开工作场所
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P501: 将内容物/容器处理到。。。
WGK Germany
2
RTECS
WP0875000
Merck Index
8916
个人防护装备
dust mask type N95 (US),Eyeshields,Faceshields,Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 A2619622 |
分析证书 | S128341 |
| A2619623 |
分析证书 | S128341 |
| A2619624 |
分析证书 | S128341 |
| I2504739 |
分析证书 | S128341 |
| I2504740 |
分析证书 | S128341 |
| G2412211 |
分析证书 | S128341 |
| E2417473 |
分析证书 | S128341 |
| E2417501 |
分析证书 | S128341 |
| B2528168 |
分析证书 | S128341 |
| C2426335 |
分析证书 | S128341 |
| C2426336 |
分析证书 | S128341 |
| D2306687 |
分析证书 | S128341 |
| D2306688 |
分析证书 | S128341 |
| D2306698 |
分析证书 | S128341 |
| D2306803 |
分析证书 | S128341 |
显示更多⌵
技术文档和文章
此产品的引用文献
引用文献
| 1. Mingguo Peng, Yicui Wang, Chunge Wu, Xuewen Cai, Yao Wu, Erdeng Du, Lu Zheng, Jiajun Fu. (2023) Investigating sulfonamides - Human serum albumin interactions: A comprehensive approach using multi-spectroscopy, DFT calculations, and molecular docking. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:37862782] [10.1016/j.bbrc.2023.10.040] |
| 2. Jing Wang, Yong Zhang, Fubin Liu, Ying Liu, Litao Wang, Guihua Gao. (2023) Preparation of a Multifunctional and Multipurpose Chitosan/Cyclodextrin/MIL-68(Al) Foam Column and Examining Its Adsorption Properties for Anionic and Cationic Dyes and Sulfonamides. ACS Omega, [PMID:37692232] [10.1021/acsomega.3c03897] |
| 3. Meiling Ping, Wenchao Lv, Chen Yang, Qian Chen, Zongwen Wang, Fengfu Fu. (2023) A Paper-Based Multicolor Colorimetric Aptasensor for the Visual Determination of Multiple Sulfonamides Based on Aptamer-Functionalized Magnetic Beads and NADH–Ascorbic Acid-Mediated Gold Nanobipyramids. Chemosensors, 11 (7): (386). [10.3390/chemosensors11070386] |
| 4. Zongwen Wang, Xiating Li, Feng Zhang, Yu Gao, Jintian Cheng, FengFu Fu. (2023) Regulating the Growth Rate of Gold Nanobipyramids via a HCl-NADH-Ascorbic Acid System toward a Dual-Channel Multicolor Colorimetric Immunoassay for Simultaneously Screening and Detecting Multiple Sulfonamides. ANALYTICAL CHEMISTRY, [PMID:37382204] [10.1021/acs.analchem.3c01928] |
| 5. Lin Li, Hongyu Zhang, Mengdan Zhang, Ting Wang, Xiaohong Hou. (2022) MIL-88B(Fe)/cellulose microspheres as sorbent for the fully automated dispersive pipette extraction towards trace sulfonamides in milk samples prior to UPLC-MS/MS analysis. ANALYTICA CHIMICA ACTA, [PMID:36257763] [10.1016/j.aca.2022.340420] |
| 6. Quan Chen, Peng Yi, Wei Dong, Yihui Chen, Liping He, Bo Pan. (2020) Decisive role of adsorption affinity in antibiotic adsorption on a positively charged MnFe2O4@CAC hybrid. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:32758730] [10.1016/j.scitotenv.2020.141019] |
| 7. Liu Yaqing, Lin Xiaodong, Ji Xiangyi, Hao Zhe, Tao Zhanhui. (2020) Smartphone-based enzyme-free fluorescence sensing of organophosphate DDVP. MICROCHIMICA ACTA, 187 (7): (1-8). [PMID:32613298] [10.1007/s00604-020-04384-7] |
| 8. Di Siyuan, Yu Jing, Chen Pin, Zhu Gangtian, Zhu Shukui. (2020) Net-like mesoporous carbon nanocomposites for magnetic solid-phase extraction of sulfonamides prior to their quantitation by UPLC-HRMS. MICROCHIMICA ACTA, 187 (2): (1-11). [PMID:31919594] [10.1007/s00604-019-4072-7] |
| 9. Minghuo Wu, Lin Fu, Yufeng Hu, Jingyun Su, Siyuan Jing, Hao Zhou, Jingjing Zhan. (2018) Multiplex On-Bead Isotope Dimethyl Labeling Coupled with Liquid Chromatography–High-Resolution Mass Spectrometry for Quantitative Analysis of Sulfonamides in Estuarine Ice. ANALYTICAL CHEMISTRY, [PMID:30221932] [10.1021/acs.analchem.8b03220] |
| 10. Xiuna Jia, Pan Zhao, Xiu Ye, Lianjun Zhang, Ting Wang, Qinyu Chen, Xiaohong Hou. (2016) A novel metal-organic framework composite MIL-101(Cr)@GO as an efficient sorbent in dispersive micro-solid phase extraction coupling with UHPLC-MS/MS for the determination of sulfonamides in milk samples. TALANTA, [PMID:28411816] [10.1016/j.talanta.2016.08.086] |
| 11. Yazhen Li, Xuewen Wu, Zhaoqian Li, Shuxian Zhong, Weiping Wang, Aijun Wang, Jianrong Chen. (2015) Fabrication of CoFe2O4–graphene nanocomposite and its application in the magnetic solid phase extraction of sulfonamides from milk samples. TALANTA, [PMID:26452959] [10.1016/j.talanta.2015.08.006] |
| 12. Longcheng Xu, Jianming Pan, Jiangdong Dai, Xiuxiu Li, Hui Hang, Zhijing Cao, Yongsheng Yan. (2012) Preparation of thermal-responsive magnetic molecularly imprinted polymers for selective removal of antibiotics from aqueous solution. JOURNAL OF HAZARDOUS MATERIALS, [PMID:22795838] [10.1016/j.jhazmat.2012.06.056] |
| 13. Lina Gao, Junfei Wu, Hai-Bo Liu, Qian Zhao, Jing Wang. (2025) Metal-mediated chitosan@mesoporous silica-based ultrasensitive fluorescent probe for the ratiometic and colorimetric detection of tetracycline antibiotics. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39924023] [10.1016/j.ijbiomac.2025.140779] |
| 14. Sai Li, Shuangying Yu, Mengyao Zhang, Zeyi Li, Hui Yu, Zhongfu Xing, Beibei Mao, Pan Zhao. (2025) Monolithic and hierarchically porous biochar/cellulose aerogel as adsorbent for microextraction in packed syringe towards trace sulfonamides in water samples prior to UPLC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:39893779] [10.1016/j.jpba.2025.116714] |
| 15. Qi Mengyu, Tu Chunyan, Li Zhaoqian, Wang Weiping, Chen Jianrong, Wang Ai-Jun. (2018) Determination of Sulfonamide Residues in Honey and Milk by HPLC Coupled with Novel Graphene Oxide/Polypyrrole Foam Material-Pipette Tip Solid Phase Extraction. Food Analytical Methods, 11 (10): (2885-2896). [10.1007/s12161-018-1271-5] |
| 16. Xiao-Ming Zou, Tiao Zhang, Yu-Hua Dong, Cui Hu, Li Yin, Yu-Ling Zheng, Mi Li, Xiao-Yu Xiao, Wei Hui. (2025) Enhanced removal of sulfonamide antibiotics in water using high-performance S-nZVI/BC derived from rice straw. JOURNAL OF ENVIRONMENTAL MANAGEMENT, [PMID:39756288] [10.1016/j.jenvman.2024.123955] |
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）