High Molecular Weight Kininogen (HK) is a nonenzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor α-Xlla. HK also forms a complex with Factor XI and accelerates its activation to XIa by α-Xlla. Also HK serves as a source of Bradykinin, a potent Vasoactive peptide important in hypotension studies. The Single Chain High MW Kininogen is greater than 95% single chain.
Extinction Coefficient (1%) = 7.01
Molecular Weight = 120,000 daltons
The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.
规格
产品名称
单链高分子量激肽原
规格或纯度
BioReagent, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA
危险品化学品经营许可证（带存储）