计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 5 篇同行评审文献引用。
概述
苯基丁酸钠刺激尿中氮元素排出。它是一种前体药物，经过 β-氧化后形成乙酸苯酯。苯基丁酸钠用于处理尿素循环疾病。它可能和月经失调，闭经和食管和胃的疼痛性粘膜炎有关。
用途
苯基丁酸钠用于作为内质网（ER）压力抑制物，用来研究ER压力在 betatrophin表达中的作用。
Information
Sodium Phenylbutyrate Sodium phenylbutyrate is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
In vitro
Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects. Phenylbutyrate significantly attenuates MPTP-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra. Phenylbutyrate attenuates the expression of the apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin-1, and the pro-angiogenic vascular endothelial growth factor in prostate cancer cells. Phenylbutyrate is found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells.
In vivo
Phenylbutyrate significantly extends survival and improved both the clinical and neuropathological phenotypes in G93A transgenic ALS mice. Phenylbutyrate administration ameliorates histone hypoacetylation observed in G93A mice and induced expression of nuclear factor-kappaB (NF-kappaB) p50, the phosphorylated inhibitory subunit of NF-kappaB (pIkappaB) and beta cell lymphoma 2 (bcl-2), but reduced cytochrome c and caspase expression. Phenylbutyrate acts to phosphorylate IkappaB, translocating NF-kappaB p50 to the nucleus, or to directly acetylate NF-kappaB p50. Phenylbutyrate increases brain histone acetylation and decreased histone methylation levels as assessed by both immunocytochemistry and Western blots in a transgenic mousemodel of Huntington\'s disease (HD). Phenylbutyrate increases mRNA for components of the ubiquitin-proteosomal pathway and down-regulated caspases implicated in apoptotic cell death, and active caspase 3 immunoreactivity in the striatum.
Cell Data
cell lines：Huh7 cells harboring HCV replicon
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
4-PBA, 4-Phenylbutyric acid | Benzenebutanoic acid, sodium salt (1:1)
规格或纯度
10mM in DMSO
英文名称
Sodium Phenylbutyrate
生化机理
苯丁酸钠是 4-苯基丁酸（4-PBA）或 4-苯基丁酸的一种盐。苯丁酸钠是一种组蛋白去乙酰化酶抑制剂，用于治疗尿素循环障碍。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
多价螯合剂
作用机制
谷氨酰胺螯合剂
名称和识别符
技术文档
高级数据
化学和物理性质
溶解性
Solubility (25°C) In vitro Water: 100 mg/mL (45.91 mM); DMSO: Insoluble; Ethanol: Insoluble;
安全和危险性（GHS）
象形图
信号词
Warning
危险声明
H319: 引起严重眼睛刺激
预防措施声明
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 L2230039 |
分析证书 | S408179 |
技术文档和文章
此产品的引用文献
引用文献
| 1. Ting Xiao, Yuan Zhi, Fangfang Tian, Feilong Huang, Xingyan Cheng, Ai Wu, Ling Tao, Zhenghong Guo, Xiangchun Shen. (2023) Ameliorative effect of black raspberry anthocyanins on diabetes retinopathy by inhibiting axis protein tyrosine phosphatase 1B-endoplasmic reticulum stress. Journal of Functional Foods, [10.1016/j.jff.2023.105696] |
| 2. Jing Cong, Yuehui Zhang, Xinming Yang, Yu Wang, Hui He, Mengying Wang. (2022) Anti-polycystic ovary syndrome effect of electroacupuncture: IMD inhibits ER stress-mediated apoptosis and autophagy in granulosa cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:36244114] [10.1016/j.bbrc.2022.10.030] |
| 3. Renhui Huang, Qi Shi, Shutian Zhang, Hong Lin, Chengzhi Han, Xinyi Qian, Yijun Huang, Xiaorong Ren, Jiayuan Sun, Nana Feng, Chunmei Xia, Meng Shi. (2022) Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats. Journal of Inflammation Research, [PMID:36091334] [10.2147/JIR.S365970] |
| 4. Zexuan Li, Xinyue Deng, Yanna Cao, Hongbo Xu, Jiangang Wang, Lamei Yuan, Hao Deng. (2025) Different GJA8 missense variants reveal distinct pathogenic mechanisms in congenital cataract. LIFE SCIENCES, [PMID:40158616] [10.1016/j.lfs.2025.123596] |
| 5. Cao Ting, Wang Xue-lian, Rao Jiang-yan, Zhu Hui-feng, Qi Hong-yi, Tian Zhen. (2024) Periplaneta americana L. extract exerts neuroprotective effects by inhibiting endoplasmic reticulum stress via AKT-dependent pathway in experimental models of Parkinson’s disease. Chinese Medicine, 19 (1): (1-24). [PMID:39538357] [10.1186/s13020-024-01029-2] |
溶液计算器
常见问题
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 1716-12-7，分子式为 C10H11NaO2，分子量为 186.18 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
本产品应如何储存？
请于?80 °C条件下保存。需超低温保存以维持规定的有效期。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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