SB-3CT, MMP2 抑制剂；MMP9 抑制剂

MMP Inhibitors

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货号 (SKU)	包装规格	是否现货	价格	数量
S408624-1ml	1ml	现货

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Compound libraries (12332)

基本描述

英文别名	2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane
规格或纯度	Moligand™, 10mM in DMSO
英文名称	SB-3CT
生化机理	SB-3CT 是一种有效的选择性明胶酶抑制剂，对 MMP-2 和 MMP-9 的_Ki值分别为 13.9 nM 和 600 nM。
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	抑制剂
作用机制	MMP2 抑制剂；MMP9 抑制剂
产品介绍	Information SB-3CT SB-3CT is an effective and selective gelatinase inhibitor with K i of 13.9 nM and 600 nM for MMP-2 and MMP-9 , respectively. In vitro SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro. In vivo In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion. Cell Data cell lines：A10 cells (Vascular SMC) Concentrations： Incubation Time： Powder Purity:≥97%

MMP14 Tchem 基质金属蛋白酶-14(Matrix metalloproteinase-14) (2 活性数据)

点击查看靶蛋白信息： MMP14

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

MMP9 Tchem 基质金属蛋白酶-9(Matrix metalloproteinase-9) (6 活性数据)

点击查看靶蛋白信息： MMP9

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

MMP2 Tchem 72 kDa IV 型胶原酶(72 kDa type IV collagenase) (6 活性数据)

点击查看靶蛋白信息： MMP2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

溶解性	Solubility (25°C) In vitro DMSO: 100 mg/mL (97.06 mM); Ethanol: 100 mg/mL (97.06 mM); Water: Insoluble;

Concentration	9-11（mmol/L）
Proton NMR spectrum	Conforms to Structure

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Xiao-lei ZHANG, Meng-ni HU, Ya-nan LI, Yao WANG, Zhen RONG, Jun MA. (2025) Effect of electroacupuncture on MMP-2/9 pathway mediated the blood-brain barrier permeability in mice with Parkinson's disease. World Journal of Acupuncture-Moxibustion, [10.1016/j.wjam.2025.01.002]

1. Xiao-lei ZHANG, Meng-ni HU, Ya-nan LI, Yao WANG, Zhen RONG, Jun MA. (2025) Effect of electroacupuncture on MMP-2/9 pathway mediated the blood-brain barrier permeability in mice with Parkinson's disease. World Journal of Acupuncture-Moxibustion, [10.1016/j.wjam.2025.01.002]