计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥95% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
SHP2-D26 is a first, potent and effective SHP2 degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent
In Vitro
SHP2-D26 (0, 3, 10, 30, 100, 300 nM; 12 hours) effectively reduces SHP2 protein in a dosedependent manner, with DC 50 values of 6.0 nM, 2.6 nM in KYSE520 and MV-4-11 cells, respectively. SHP2-D26 (100 nM; 0, 2, 4, 8, 12, 24 hours) reduces the SHP2 protein level within 4 h and completes SHP2 depletion with 8 h in KYSE520 and MV-4-11 cells. SHP2-D26 (0-100 μM for KYSE520 cells; 0-10 nM for MV-4-11 cells; 4 days) achieves IC 50 values of 0.66 μM, 0.99 nM in KYSE520 and MV-4-11 cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: KYSE520 and MV-4-11 cells Concentration: 0-100 μM for KYSE520 cells; 0-10 nM for MV-4-11 cells Incubation Time: 4 days Result: Achieved IC 50 values of 0.66 μM, 0.99 nM in KYSE520 and MV-4-11 cells, respectively. Western Blot AnalysisCell Line: KYSE520 and MV-4-11 cells Concentration: 0, 3, 10, 30, 100, 300 nM Incubation Time: 12 hours Result: Reduced SHP2 protein in a dosedependent manner, with DC 50 values of 6.0 and 2.6 nM in KYSE520 and MV-4-11 cells, respectively. Western Blot AnalysisCell Line: KYSE520 and MV-4-11 cells Concentration: 100 nM Incubation Time: 0, 2, 4, 8, 12, 24 hours Result: Reduced the SHP2 protein level within 4 h and completed SHP2 depletion with 8 h.
Form:Solid
IC50& Target:SHP2
规格
规格或纯度
≥95%
英文名称
SHP2-D26
生化机理
SHP2-D26 是第一种强效的 SHP2 降解剂。SHP2-D26 诱导 SHP2 降解需要与 VHL-1 和 SHP2 蛋白结合。SHP2-D26 还依赖于内切酶和蛋白酶体。
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥95%
名称和识别符
分子类型
小分子
分子量
1115.89
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 83.33 mg/mL (74.68 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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