计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-20°C储存,充氩。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)
In Vitro
SG3199 is potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with a mean GI 50 of 151.5 pM. Cells defective in DNA repair protein ERCC1 or homologous recombination repair show increased sensitivity to SG3199 and the drug is only moderately susceptible to multidrug resistance mechanisms. ?\nSG3199 is highly efficient at producing DNA interstrand cross-links in naked linear plasmid DNA and dose-dependent cross-linking is observed in cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The in vitro binding of [ 3 H]-SG3199 to the plasma proteins of rat (Sprague Dawley), cynomolgus monkey and human at concentrations of 0.8, 5 and 50?ng/mL is determined. Plasma protein binding is high in all species; rat ～97%, cynomolgus monkey ～90% and human ～95% . ?\nFollowing i.v. administration at 0.1 μg/kg, 0.5 μg/kg and 1?μg/kg, SG3199 shows a very rapid clearance in rats. In the 0.5 μg/kg and 1?μg/kg dose groups, the rapid clearance was between 1000 and 1500?mL/h/kg, with a T 1/2 between 8 and 42?minutes . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Pyrrolobenzodiazepines
规格
规格或纯度
≥98%
英文名称
SG3199
生化机理
SG3199 是一种具有细胞毒性的 DNA 小沟链间交联吡咯并二氮杂卓（PBD）二聚体。SG3199 是 ADC 有效载荷 Tesirine（SG3249）的释放弹头成分。
储存条件
避光,-20°C储存,充氩
运输条件
超低温运输
纯度
≥98%
名称和识别符
分子类型
小分子
IUPAC Name
3-[5-[[(6aR)-2-methoxy-8-methyl-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentoxy]-2-methoxy-8-methyl-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
INCHI
1S/C33H36N4O6/c1-20-10-22-16-34-26-14-30(28(40-3)12-24(26)32(38)36(22)18-20)42-8-6-5-7-9-43-31-15-27-25(13-29(31)41-4)33(39)37-19-21(2)11-23(37)17-35-27/h12-19,22-23H,5-11H2,1-4H3/t22-,23?/m1/s1
InChi Key
YMTZZJOPSATRTO-WTQRLHSKSA-N
Smiles
CC1=CN2C(C1)C=NC3=CC(=C(C=C3C2=O)OC)OCCCCCOC4=C(C=C5C(=C4)N=CC6CC(=CN6C5=O)C)OC
PubChem CID
分子量
584.66
技术文档
高级数据
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : 130 mg/mL (222.35 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）