计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3) , with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research
In Vitro
STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2. STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7 cells with IC 50 s of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM, respectively. STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1. STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation. STAT3-IN-3 inhibits STAT3 DNA-binding activity. STAT3-IN-3 (1-4 μM; 24 hours) increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway. STAT3-IN-3 (1-4 μM; 24 hours) can induce the cleavage of caspase-9, caspase-3 and PARP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-231 cells, HCT-116 cells, HepG2 cells, MCF-7cells Concentration: MTT assay Incubation Time: 48 hours Result: Exhibited anti-proliferative activity. Apoptosis AnalysisCell Line: MDA-MB-231 cells Concentration: 0 μM, 1 μM, 2 μM, 4 μM Incubation Time: 24 hours Result: Induced the apoptosis of MDA-MB-231 cells dose-dependently and the apoptosis rates. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 0 μM, 1 μM, 2 μM, 4 μM Incubation Time: 24 hours Result: Induced the cleavage of caspase-9, caspase-3 and PARP.
In Vivo
STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult female BALB/c mice (6 weeks of age) Dosage: 10 mg/kg, 20 mg/kg Administration: Intraperitoneal injection, daily, for 14 days Result: Significantly inhibited tumor volume.
Form:Solid
IC50& Target:STAT3
规格
规格或纯度
≥98%
英文名称
STAT3-IN-3
生化机理
STAT3-IN-3 是信号转导和转录激活因子 3（STAT3）的一种强效选择性抑制剂，具有抗增殖活性。STAT3-IN-3 能诱导乳腺癌细胞凋亡。STAT3-IN-3 是一种很有前景的线粒体靶向 STA
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥98%
名称和识别符
分子类型
小分子
Smiles
BrC1=C2C(S(C(C(N3CCN(C(C4=CC5=CC=C(N(CC)CC)C=C5OC4=O)=O)CC3)=O)=C2)(=O)=O)=CC=C1
分子量
600.48
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 5 mg/mL (8.33 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?20 °C条件下保存。需冷冻保存以维持规定的有效期。
本产品如何运输？
本产品采用保温箱配冰袋运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 2361304-26-7，分子式为 C27H26BrN3O6S，分子量为 600.48 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
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