计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,充氩,干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK .
In Vitro
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium), as a novel cardiovascular hormone, has a significant inhibitory effect on myocardial fibrosis in noninfarcted areas. Sincalide ammonium also plays a positive role in fighting inflammation, apoptosis and collagen deposition. CCK‐8 (ammonium) protects H9c2 cardiomyoblasts from Ang II‐induced apoptosis partly via activation of the CCK1 receptor and the phosphatidyqinositol‐3 kinase/protein kinase B (PI3K/Akt) signaling pathway. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assaysup> Cell Line: H9c2 cells Concentration: 0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time: 24 h Result: Attenuated Ang II‐induced toxicity in H9c2 cells Apoptosis AnalysisCell Line: H9c2 cells Concentration: 0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time: 24 h Result: Decreased apoptotic cells, and prevented Ang II‐induced cytotoxicity that involves modulation of the PI3K/Akt pathway. Western Blot AnalysisCell Line: H9c2 cells Concentration: 0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time: 24 h Result: Expressed the protein and mRNAs of CCK and both its receptors in H9c2 cells. RT-PCRCell Line: H9c2 cells Concentration: 0.001, 0.01, 0.1, 1, 10, or 100 μmol/L Incubation Time: 24 h Result: Increased the protein and mRNA expression levels of CCK and decreased CCK 1 receptor expression levels at both the protein and mRNA levels with Ang II stimulation markedly.
In Vivo
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) alleviates fibrosis in the noninfarcted regions and delay the left ventricular remodeling and the progress of heart failure in a MI rat model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MI rat modelDosage: 50 μg/kg Administration: i.p.; 50 μg/kg/d; for 4 weeks Result: Had significant inhibitory effect on myocardial fibrosis in noninfarcted areas.
Form:Solid
规格
别名
辛卡利特铵
规格或纯度
≥99%
英文名称
Sincalide ammonium
生化机理
辛卡列铵（胆囊收缩素八肽铵，CCK-8铵）是一种快速起效的胆囊收缩素（CCK）氨基酸多肽激素类似物，可用于静脉注射，用于排气后胆囊造影。辛卡利铵是一种主要的生物活性 S
储存条件
避光,充氩,干燥,-80℃储存
运输条件
特低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
1160.30
技术文档
高级数据
化学和物理性质
溶解性
H2O : 12.5 mg/mL (10.77 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C、避光、氩气保护、干燥条件下保存。本品在氩气保护下供应，每次取用后请在惰性气体下重新密封。
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥99%。批次的具体数值以分析证书（COA）为准。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 70706-98-8，分子式为 C49H65N11O16S3，分子量为 1160.30 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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