级别和纯度: 无动物源?无动物源(Animal Free)—— 不含动物源成分生产,降低污染风险。适用于避免动物源材料的生物制造和培养。重组?重组(Recombinant)—— 通过重组表达生产,序列确定、批次稳定。适用于来源明确、无动物源的可重现蛋白。≥98%(SDS-PAGE&HPLC)expressed in E. coli
SDF-1α (stromal cell-derived factor 1 α) and β are stromal derived CXC chemokines, and signal through the CXCR4 (C-X-C motif chemokine receptor). SDF1α is an isoform of CXCL12 (C-X-C motif chemokine 12, also referred to as SDF-1). The gene is mapped to human chromosome 10q11. Recombinant human SDF-1a is an 8.0kDa protein containing 68 amino acid residues.
Application:
SDF-1α (stromal cell-derived factor 1 α) human has been used to study the role of SDF-1α in cell migration and survival after TGF (transforming growth factor)-β-induced EMT (epithelial–mesenchymal transition) in hepatoma cells. It has been used to study podia formation, migration, proliferation and cell-cell adhesion of human hematopoietic progenitor cells in presence of SDF-1α.
SDF-1α (stromal cell-derived factor 1 α) human has been used in the chemotaxis assay of neural crest cells (NCCs) and as a component of Dulbecco′s modified Eagle′s medium (DMEM) in migration assay of human mesenchymal stem cells (hMSCs).
规格
产品名称
人SDF-1α
规格或纯度
无动物源, 重组, ≥98%(SDS-PAGE&HPLC), expressed in E. coli
生化机理
SDF-1α(基质细胞衍生因子 1α)和 β化学吸引 B 细胞和 T 细胞,并已被证明诱导 CD34 + 干细胞的迁移。 SDF-1 主要在炎症和衰竭的心肌中表达。参与炎症、增殖、成瘤和转移。SDF-1 蛋白在表达 CXCR4(C-X-C 基序趋化因子受体 4)的细胞中发挥 HIV(人类免疫缺陷病毒)抑制活性。在乳腺癌、卵巢癌和甲状腺乳头状癌中表达上调。增强缺血组织中的血管生成。SDF1 在 CXCR4 的帮助下也参与缺血性卒中后的神经保护。