巯基官能化甲氧基聚乙二醇(mPEG-SH)是一种单官能PEG衍生物,可用于修饰蛋白质、肽和其他材料。巯基对金表面也有很高的亲和力,广泛用于金纳米粒子或金膜改性。聚乙二醇化可以提高肽和蛋白质的溶解度和稳定性,降低其免疫原性。它还可以抑制带电分子与改性表面的非特异性结合。
Thiol functionalized methoxyl polyethylene glycol, PEG thiol (mPEG-SH) is a monofunctional PEG derivative that can be used to modify proteins, peptides and other materials. Thiol groups also have high affinity to gold surface and are widely used for gold nanoparticles or gold film modification. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.