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| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
1,8,9-三羟基蒽
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T420709-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 二羟蒽酚 | 1,8,9-蒽三酚 | 蒽林 | 1,8-二羟基蒽-9(10H)-酮 | 地蒽酚 | 1,8,9-蒽三醇 | 1,8-二羟基-9(10H)-蒽酮 |
|---|---|
| 英文别名 | anthralin | Dithranol | 1143-38-0 | 1,8-Dihydroxyanthrone | Cignolin | 1,8-Dihydroxy-9-anthrone | Chrysodermol | Cigthranol | 1,8-Dihydroxyanthracen-9(10H)-one | 9(10H)-Anthracenone, 1,8-dihydroxy- | Batridol | Psoriacid-Stift | Anthra-Derm | Drithoscalp | Derobin | DrithoCreme | Lasan | |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | 1,8,9-Trihydroxyanthracene |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
地蒽酚（1，8-二羟基-9-蒽酮）也称为 anthralin。地蒽酚是一种蒽衍生物，是一种自由基可产生线粒体毒素，线粒体毒素可诱导角质细胞发生细胞凋亡。 Dithranol (Anthralin) 是一种蒽醌衍生物，具有较强的抗银屑病作用。Dithranol 能抑制 DNA 的复制和修复。 Dithranol (1, 8 - dihydroxy-9-anthrone) is also called as anthralin. It is a vital topical antipsoriatic drugs. Dithranol, an athracene derivative, is a free radical generating mitochondrial poison that induces apoptosis in keratinocytes. |
产品属性
| ALogP | 3.2 |
|---|
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Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
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TSHR
Tclin
Thyroid stimulating hormone receptor
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DRD1
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Dopamine D1 receptor
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ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
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PTGS1
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SLC6A2
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Norepinephrine transporter
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SLC6A4
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ADRA1A
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OPRM1
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Mu opioid receptor
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DRD3
Tclin
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SLC6A3
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(10535 活性数据)
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KCNH2
Tclin
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(29587 活性数据)
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PDE3A
Tclin
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(3309 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HTR2B
Tclin
Serotonin 2b (5-HT2b) receptor
(10323 活性数据)
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|---|
TBXA2R
Tclin
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(5717 活性数据)
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THRB
Tclin
Thyroid hormone receptor beta-1
(7926 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PDE4A
Tclin
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(1943 活性数据)
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ADORA3
Tchem
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HRH3
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Tchem
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(1512 活性数据)
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KDR
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Vascular endothelial growth factor receptor 2
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ALDH1A1
Tchem
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M14
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OVCAR-3
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OVCAR-4
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OVCAR-5
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OVCAR-8
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Histone deacetylase 6 (222 活性数据)
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GCN5
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rep
Replicase polyprotein 1ab (378 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ARG1
Arginase-1 (70 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mapt
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Rorc
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SARS-CoV-2 (38078 活性数据)
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pyrH
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 214-538-0 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 1,8-dihydroxy-10H-anthracen-9-one |
| INCHI | InChI=1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2 |
| InChi Key | NUZWLKWWNNJHPT-UHFFFAOYSA-N |
| Canonical SMILES | C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O |
| Isomeric SMILES | C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O |
| WGK Germany | 3 |
| RTECS | CB8927000 |
| 关联CAS | 480-22-8 |
| PubChem CID | 2202 |
| 分子量 | 226.23 |
| Beilstein号 | 2054360 |
化学和物理性质
| 敏感性 | 对湿度敏感 |
|---|---|
| 熔点 | 181°C |
| 分子量 | 226.230 g/mol |
| XLogP3 | 3.200 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 226.063 Da |
| 单同位素质量Monoisotopic Mass | 226.063 Da |
| 拓扑极表面积Topological Polar Surface Area | 57.500 Ų |
| 重原子数Heavy Atom Count | 17 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 287.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | CB8927000 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
技术规格说明书
| concentration | 9.0-11.0（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
| 1. Zhen-Zong Bao, Zhi-Feng Chen, Si-Qi Lu, Guangzhao Wang, Zenghua Qi, Zongwei Cai. (2021) Effects of hydroxyl group content on adsorption and desorption of anthracene and anthrol by polyvinyl chloride microplastics. SCIENCE OF THE TOTAL ENVIRONMENT, 790 (148077). [PMID:34090159] [10.1016/j.scitotenv.2021.148077] |
| 2. Hu Ao, Li Jing, Tang Wei, Liu Ge, Zhang Haiwei, Liu Chunlan, Chen Xulin. (2020) Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase. Frontiers in Microbiology, 11 (178). [PMID:32132985] [10.3389/fmicb.2020.00178] |
| 3. Sammar Fathy Elhabal, Nashwa Abdelaal, Saeed AS Al-Zuhairy, Mohamed Fathi Mohamed Elrefai, Mohamed Mansour Khalifa, Mohammad Ahmad Khasawneh, Ahmed Mohsen Elsaid Hamdan, Passant M Mohie, Rania A Gad, Soad L Kabil, Mohamed Kandeel El-Ashery, Bhaskara R Jasti, Nahla A Elzohairy, Nehal Elfar, Tayseer Elnawawy, Fatma E Hassan, Mohamed Ahmed El-Nabarawi. (2024) Revolutionizing Psoriasis Topical Treatment: Enhanced Efficacy Through Ceramide/Phospholipid Composite Cerosomes Co-Delivery of Cyclosporine and Dithranol: In-Vitro, Ex-Vivo, and in-Vivo Studies. International Journal of Nanomedicine, [PMID:38344440] [10.2147/IJN.S443812] |
参考文献
| 1. Zhen-Zong Bao, Zhi-Feng Chen, Si-Qi Lu, Guangzhao Wang, Zenghua Qi, Zongwei Cai. (2021) Effects of hydroxyl group content on adsorption and desorption of anthracene and anthrol by polyvinyl chloride microplastics. SCIENCE OF THE TOTAL ENVIRONMENT, 790 (148077). [PMID:34090159] [10.1016/j.scitotenv.2021.148077] |
| 2. Hu Ao, Li Jing, Tang Wei, Liu Ge, Zhang Haiwei, Liu Chunlan, Chen Xulin. (2020) Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase. Frontiers in Microbiology, 11 (178). [PMID:32132985] [10.3389/fmicb.2020.00178] |
| 3. Sammar Fathy Elhabal, Nashwa Abdelaal, Saeed AS Al-Zuhairy, Mohamed Fathi Mohamed Elrefai, Mohamed Mansour Khalifa, Mohammad Ahmad Khasawneh, Ahmed Mohsen Elsaid Hamdan, Passant M Mohie, Rania A Gad, Soad L Kabil, Mohamed Kandeel El-Ashery, Bhaskara R Jasti, Nahla A Elzohairy, Nehal Elfar, Tayseer Elnawawy, Fatma E Hassan, Mohamed Ahmed El-Nabarawi. (2024) Revolutionizing Psoriasis Topical Treatment: Enhanced Efficacy Through Ceramide/Phospholipid Composite Cerosomes Co-Delivery of Cyclosporine and Dithranol: In-Vitro, Ex-Vivo, and in-Vivo Studies. International Journal of Nanomedicine, [PMID:38344440] [10.2147/IJN.S443812] |