计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 ( DP 2 , also known as CRTH2 ) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [ 3 H] PGD2 from human recombinant DP 2 ( K i =13 nM), rat recombinant DP 2 ( K i =3 nM), and human native DP 2 ( K i =4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils
In Vitro
Timapiprant sodium (OC000459 sodium) (0.0001 μM-10 μM; 5 hours) inhibits chemotaxis (IC 50 =0.028 μM) of human Th2 lymphocytes and cytokine production (IC 50 =0.019 μM) by human Th2 lymphocytes. Timapiprant sodium (OC000459 sodium) (1 μM) inhibits the activation of Th2 cells and eosinophils in response to supernatants from IgE/anti-IgE-activated human mast cells. Timapiprant sodium (OC000459 sodium) (1 nM-1000 nM; 16 hours) inhibits the anti-apoptotic effect of PGD2 on Th2 cells with an IC 50 of 0.035 uM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Th2 Cells Concentration: 0.0001 μM-10 μM Incubation Time: 16 hours Result: Inhibited the antiapoptotic effect of PGD2.
In Vivo
Timapiprant sodium (OC000459 sodium) (gavage; 2 mg/kg, 10 mg/kg) inhibits blood eosinophilia induced by 13,14-dihydro-15-keto-PGD2 (DK-PGD2) in Rat (ED 50 =0.04 mg/kg) . Timapiprant sodium (OC000459 sodium) (gavage; 0.01 mg/kg, 0.1 mg/kg, 1.0 mg/kg) inhibits airway eosinophilia in response to an aerosol of DK-PGD2 in guinea pigs (ED 50 =0.01 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Ki: 0.013 μM (human recombinant DP2),0.003 μM (rat recombinant DP2) and 0.004 μM (human native DP2)
规格
别名
替马匹兰钠
规格或纯度
≥99%
英文名称
Timapiprant sodium
生化机理
替马扑仑钠（OC000459 sodium）是一种强效、选择性和口服活性的 D 类前列腺素受体 2（DP 2，又称 CRTH2）拮抗剂。替马扑仑钠（OC000459 钠）能强效置换人重组 DP 2 中的 [ 3 H] PGD2（K i =13 nM）。
储存条件
2-8°C储存
运输条件
低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
Smiles
O=C(O[Na])CN1C2=CC=C(F)C=C2C(CC3=NC4=C(C=CC=C4)C=C3)=C1C
分子量
370.35
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 100 mg/mL (270.01 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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