计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA inhibits thrombin- and AY-NH 2 -induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology.
In Vitro
tcY-NH2 TFA (0-500 μM) inhibits AYPGKF-NH 2 (10 μM)-induced platelet (obtained from male albino Sprague–Dawley rats) aggregation, with an IC 50 value of 95 μM. tcY-NH2 TFA potently activates aorta relaxation (RA) and gastric (LM) contraction, with IC 50 values of 64 μM (RA) and 1 μM (LM). tcY-NH2 TFA (Tc-YPGKF-NH 2 , 400 μM, 5 min) prevents endostatin release and platelet aggregation induced by thrombin or by AY-NH 2. tcY-NH2 TFA (5 μM, 15 min) decreases infarct size (IS) by 51%, and increases recovery of ventricular function by 26% in an isolated heart model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
tcY-NH2 TFA (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology. tcY-NH2 TFA (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4 + Tregs within the draining lymph nodes in burn injury mice model. tcY-NH2 TFA (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Brain death (BD) rat modelDosage: 0.6 mg/kg for a single dose Administration: Tail vein injection for a single dose Result: Reduced blood platelet activation and hepatic platelet accumulation. Attenuated the inflammatory response and apoptosis in the livers. Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD). Animal Model: Burn injury model of C57BL/6 N miceDosage: 0.6 mg/kg for a single dose Administration: Intraperitoneal injection Result: Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis. Animal Model: BALB/c mice Dosage: 40 ng/kg for a single dose Administration: Intrapleural injection Result: Abolished the number of rolling and adhering neutrophils on the vessel wall. Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.
Form:Solid
IC50& Target:PAR4
规格
别名
tcY-NH2三氟乙酸
规格或纯度
≥99%
英文名称
tcY-NH2 TFA
生化机理
tcY-NH2（（反式-肉桂酰）-YPGKF-NH2）反式脂肪酸是一种强效的选择性 PAR4 拮抗剂多肽。tcY-NH2 反式脂肪酸能抑制凝血酶和 AY-NH 2 诱导的血小板聚集和内抑素释放，可用于炎症、免疫学和细胞生物学研究。
储存条件
干燥,-80℃储存
运输条件
特低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
Smiles
C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)/C=C/C3=CC=CC=C3)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N.C(=O)(C(F)(F)F)O
Isomeric SMILES
C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)/C=C/C3=CC=CC=C3)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N.C(=O)(C(F)(F)F)O
PubChem CID
分子量
853.88
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 100 mg/mL (117.11 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥99%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?80 °C、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 1262750-73-1，分子式为 C42H50F3N7O9，分子量为 853.88 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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