计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥96% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria , fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds.
In Vitro
Tyrothricin is a mixture of polypeptides, consisting of 50%-70% tyrocidines and 25%-50% gramicidins. The group of tyrocidines is basic, cyclic peptides, whereas the fraction of gramicidins is neutral, linear peptides. Besides physiological and essential L-amino acids, the components of Tyrothricin also contain D-amino acids. Tyrothricin is produced by the gram-positive aerobic sporeforming bacterium Bacillus brevis (Strain ATCC 8185) during its sporulation phase via the nonribosomal pathway. The efficacy spectrum of Tyrothricin mainly covers gram-positive but also several gram-negative bacteria. Corynebacteria and staphylococci show a broader range of Tyrothricin concentrations for inhibition (2-256 μg/mL). In contrast to the gramicidin fraction alone, Tyrothricin is able to inhibit all Staphylococcus strains at a maximum concentration of 128 μg/mL. Among the gram-negative organisms, gonococci and meningococci were the most sensitive germs (96 μg/mL). Tyrothricin exerts fungicidal effects on a variety of Candida species.\nTyrothricin shows an anti-infectious activity against parainfluenza virus (type Sendai). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In animal models using HSV type 1, a pre-incubation of the virus suspension with Tyrothricin could significantly decrease the lethality in mice. The effect could only be shown after a direct contact between Tyrothricin and the virus . Nevertheless disruption of the integrity of eukaryotic membranes is observed at higher Tyrothricin concentrations in vitro. This effect is exemplified as hemolytic activity of Tyrothricin in in vitro studies and when applied to animals i.v.. In contrast to an intravenous (LD 50 mouse: 3,7 mg/kg) and an intraperitoneal (LD 50 mouse: 20-45 mg/kg) application the oral application is very well tolerated, as Tyrothricin is destroyed in the gastro-intestinal tract . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
规格
别名
酪丝菌素
规格或纯度
≥96%
英文名称
Tyrothricin
生化机理
酪氨酸是一种多肽抗生素混合物，从酿酒芽孢杆菌（Bacillus brevis）中分离出来，由酪氨酸和苎麻素组成。酪氨酸酶对细菌、真菌和某些病毒具有活性。含酪氨酸的制剂可用于治疗咽喉炎、溃疡、溃疡性结肠炎、溃疡性结肠炎和溃疡性结肠炎。
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥96%
名称和识别符
分子类型
小分子
Smiles
[Tyrothricin]
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥96%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?20 °C条件下保存。需冷冻保存以维持规定的有效期。
本产品如何运输？
本产品采用保温箱配冰袋运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 1404-88-2。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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