F2604426计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
Urolithin C
有货
为什么选择此级别
Moligand™ 级 提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion . Urolithin C is a L-type Ca 2+ channel opener and enhances Ca 2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation
In Vitro
Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells. Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis. Urolithin C treatment induces apoptosis and S phase cell cycle arrest. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: INS-1 cells Concentration: 20 μM, 100 μM Incubation Time: 1 hour Result: Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.
In Vivo
The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V 1 /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Insulin secretion, L-type Ca 2+ channel, Reactive oxygen species (ROS),Apoptosis
规格
别名
尿石素C | 3,8,9-三羟基-6H-苯并[c]色烯-6-酮
英文别名
3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one | 3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one | 3,8,9-Trihydroxyurolithin
规格或纯度
Moligand™, ≥99%
英文名称
Urolithin C
生化机理
卵磷脂 C 是鞣花酸的一种肠道微生物代谢产物，是一种葡萄糖依赖性胰岛素分泌激活剂。卵磷脂 C 是一种 L 型 Ca 2+ 通道开启剂，能增强 Ca 2+ 的流入。尿胆素 C 通过线粒体介导的途径诱导细胞凋亡。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激活剂
纯度
≥99%
名称和识别符
技术文档
高级数据
关联靶点（其它种属）
Escherichia coli (133304 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
DMSO : 50 mg/mL (204.75 mM; Need ultrasonic)
分子量
244.200 g/mol
XLogP3
2.000
氢键供体数Hydrogen Bond Donor Count
3
氢键受体数Hydrogen Bond Acceptor Count
5
可旋转键计数Rotatable Bond Count
0
精确质量Exact Mass
244.037 Da
单同位素质量Monoisotopic Mass
244.037 Da
拓扑极表面积Topological Polar Surface Area
87.000 Ų
重原子数Heavy Atom Count
18
形式电荷Formal Charge
0
复杂度Complexity
344.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
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