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提供 ≥98% 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC 50 s of 11.46, 9.36 and 9.85 for human CRF 1 , human CRF 2 and rat CRF 2α receptors in CHO cells, and K i s of 0.4, 1.8, and 5.7 nM for hCRF 1 ,
Appearance:Solid
IC50& Target:pEC50: 11.46 (human CRF 1 , CHO cells), 9.36 (human CRF 2 , CHO cells), 9.85 (rat CRF 2α , CHO cells) Ki: 0.4 nM (hCRF 1 , cell assay), 1.8 nM (rCRF 2α , cell assay), and 5.7 nM (mCRF 2β , cell assay)
In Vitro:Urotensin I is 2-3 times more potent than CRF or sauvagine in stimulating ACTH release from a superfused goldfish anterior pituitary cell column. Rat tail artery strips were incubated in the presence of 4 x 10(-3) M theophylline and Urotensin I (UI).
In Vivo:Intraperitoneal injections of urotensin I, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in
Biological Activity:Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC 50 s of 11.46, 9.36 and 9.85 for human CRF 1 , human CRF 2 and rat CRF 2α receptors in CHO cells, and K i s of 0.4, 1.8, and 5.7 nM for hCRF 1 ,