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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation ( VISTA ). VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model.