Valproic Acid (NSC 93819) sodium salt Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine he
In vitro

Valproic acid acts through a distinct pathway that involves direct inhibition of histone deacetylase (IC(50) for HDAC1 = 0.4 mM). Valproic acid mimics the histone deacetylase inhibitor trichostatin A, causing hyperacetylation of histones in cultured cells. Valproic acid, like trichostatin A, also activates transcription from diverse exogenous and endogenous promoters. Valproic acid and trichostatin A have remarkably similar teratogenic effects in vertebrate embryos, while non-teratogenic analogues of valproic acid do not inhibit histone deacetylase and do not activate transcription. Valproic acid induces proliferation of peroxisomes in the rodent liver. Valproic acid at a concentration of 1 mM induces relief of this repression by Gal4 fusions of N‐CoR, TR or PPARδ in a cell line expressing the ligand‐binding domain of PPARδ fused to the DNA‐binding domain of the glucocorticoid receptor (GR) together with a GR‐controlled reporter gene. Valproic acid induces accumulation of hyperacetylated histone and inhibits HDAC activity. Valproic acid induces a specific type of differentiation characterized by reduced proliferation, morphological alterations, marker gene expression and particularly the accumulation of the AP-2 transcription factor as a potential marker of neuronal or neural crest cell-like differentiation in F9 teratocarcinoma cells. Valproic acid impairs cell proliferation or survival as indicated by decreased incorporation of [³H]thymidine in F9 and P19 teratocarcinoma cells.

In vivo

Valproic acid delays growth of the primary tumors in the MT‐450 rat breast cancer model.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

规格

英文别名

Sodium valproate | sodium 2-propylpentanoate

规格或纯度

10mM in DMSO

英文名称

Valproic Acid (NSC 93819) sodium salt

生化机理

丙戊酸钠（NSC 93819，Sodium valproate）是一种 HDAC 抑制剂，可选择性地诱导 HDAC2 蛋白质体降解，用于治疗癫痫、双相情感障碍和预防偏头痛。丙戊酸可诱导小细胞肺癌（SCLC）细胞中的 Notch1 信号传导。丙戊酸正在研究用于治疗艾滋病和各种癌症。丙戊酸（VPA）通过上调 BNIP3 诱导自噬和有丝分裂，通过上调 PGC-1α 诱导线粒体生物生成。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

作用机制

琥珀酸半醛脱氢酶抑制剂

名称和识别符

EC号

213-961-8

分子类型

小分子

Isomeric SMILES

CCCC(CCC)C(=O)[O-].[Na+]

PubChem CID

16760703

分子量

166.2

Reaxy-Rn

4212221

技术文档

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高级数据

化学和物理性质

溶解性

Solubility (25°C) In vitro Water: 100 mg/mL warmed with 50ºC Water: bath (61.7 mM); DMSO: Insoluble; Ethanol: Insoluble;

安全和危险性（GHS）

象形图

GHS08, GHS07

信号词

Danger

危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H302: 吞食有害

H360: 可能损害生育力或未出生的孩子

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P330: 漱口

P203: 使用前，获取、阅读并遵守所有安全说明。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P301+P317: 如果被吞咽：请寻求医疗帮助。

P318: 如果暴露或担心，请就医。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。

WGK Germany

RTECS

YV7876000

Merck Index

9913

个人防护装备

dust mask type N95 (US)， Eyeshields， Gloves

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批号(Lot Number)	证书类型	货号
A2303676	分析证书	V408675

技术文档和文章

表观遗传调控剂

目录：技术文章

探索主题:

极光激酶表观遗传学 DNMTs 组蛋白甲基转移酶抑制剂 HDACs

Epigenetic Modifiers

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Aurora Kinases DNMTs HDACs Epigenetics Histone Methyltransferase Inhibitors

组蛋白去乙酰化酶抑制剂

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HDAC抑制剂

Histone Deacetylase Inhibitors

目录：技术文章

探索主题:

HDAC inhibitors

此产品的引用文献

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引用文献

1. Yuan Yuyang, Li Tianyu, Ye Zhichao, Feng Yuyao, Chen Zhe, Wang Yusen, Sun Yiqiao, Wu Haoyu, Yang Zhaodong, Wang Yifan, Zhang Yiran, Huang Liquan, Liang Bo. (2022) A One-Step Electropolymerized Biomimetic Polypyrrole Membrane-Based Electrochemical Sensor for Selective Detection of Valproate. Frontiers in Bioengineering and Biotechnology, [PMID:35242753] [10.3389/fbioe.2022.851692]
2. Guo Qing, Gan Jun, Wang En-ze, Wei Yu-ming, Xu Jie, Xu Yun, Zhang Fei-fei, Cui Meng, Jia Meng-xing, Kong Ming-jian, Tang Qiong-yao, Zhang Zhe. (2025) Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model. ACTA PHARMACOLOGICA SINICA, [PMID:39870847] [10.1038/s41401-024-01457-8]
3. Yingjun Xu, Yiming Han, Li Liu, Shanshan Han, Shibiao Zou, Bo Cheng, Fengbang Wang, Xunwei Xie, Yong Liang, Maoyong Song, Shaochen Pang. (2024) Highly sensitive response to the toxicity of environmental chemicals in transparent casper zebrafish. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:39032757] [10.1016/j.scitotenv.2024.174865]
4. Hongshan Li, Rongqian Mo, Jiayu Yue, Rongrong Cheng, Dianyu Li, Yusuf M. Idres, Yanmei Yang, Yanqiao Wen, Xiangrong Li, Ruofei Feng. (2024) Sodium valproate promotes low metabolism and high protein expression in CHO-engineered cell lines. BIOCHEMICAL ENGINEERING JOURNAL, [10.1016/j.bej.2024.109362]
5. Yang Zhao, Feiya Zhu, Jiayu Xie, Yiting Wang, Motlalepula Matsabisa, Minke Tang. (2025) Panax notoginseng Flower Extract Attenuates Pentylenetetrazole-Induced Epilepsy by Restoring Glutamate Homeostasis. Brain Sciences, 15 (10): (1110). [PMID:41154204] [10.3390/brainsci15101110]
6. Xin Gao, Xinjia Li, Yuanteng Zheng, Lijie Xia, Haonan Li, Yuqing Li, Attila Sik, Kechun Liu, Meng Jin. (2025) Rapid antiepileptic activity identification of isopimpinellin using a multi-model of epilepsy based on behavior-biomarker-BBB screening pipeline. PHYTOMEDICINE, [PMID:41351986] [10.1016/j.phymed.2025.157636]
7. Yuwei Zhu, Wenbo Gao, Jianlin Zheng, Ye Bai, Xinyu Tian, Tengjin Huang, Zebin Lu, De Dong, Anqi Zhang, Changyou Guo, Zhiwei Huang. (2025) Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation. IMMUNITY, [PMID:40334665] [10.1016/j.immuni.2025.04.012]
8. Xiangxi Meng, Yumo Tian, Sen Hu, Lili Wang, Yuxian Zhong, Kui Sun, Minghua Du. (2026) The protective effect of sodium valproate on rats with severe scald combined with seawater immersion. EUROPEAN JOURNAL OF MEDICAL RESEARCH, [PMID:41709307] [10.1186/s40001-026-04043-2]
9. Guoyue Wan, Keyu Zhao, Min Wang, Ren-He Xu, Meiling Jin, Liwei Liu. (2026) The Marine-Derived Cyclopentapeptide Turnagainolide B Suppresses Melanoma via Autophagic Flux Disruption and Inhibits Tumorigenesis In Vivo. Marine Drugs, 24 (7): (235). [PMID:42505975] [10.3390/md24070235]
10. Xiaojing Zhang, Jiale Song, Hongfang Mu, Rong Wang, Wenbin Li. (2026) Effect of high altitude on the pharmacokinetics and pharmacodynamics of valproate in epileptic rats. Frontiers in Pharmacology, [PMID:42460023] [10.3389/fphar.2026.1829626]