计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
VPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD) , with IC 50 of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer
In Vitro
VPC-14449 (0.01-100 μM; 24 h) inhibits AR-transcriptional activity and cell viability in LNCaP, C4-2, MR49F, and 22Rv1 cells. VPC-14449 (0.01-100 μM; 24 h) dose-dependently inhibits the transiently expressed full-length human AR in PC3 cells (IC 50 =0.34 μM) without affecting AR protein expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: LNCaP, C4-2, MR49F, and 22Rv1 cells Concentration: 0.01, 0.1, 10, 100 μM Incubation Time: 24 hours Result: Suppressed the growth of every tested cell line. Western Blot AnalysisCell Line: LNCaP, C4-2, MR49F, and 22Rv1 cells Concentration: 0.01, 0.1, 10, 100 μM Incubation Time: 24 hours Result: Inhibited endogenous AR transactivation in LNCaP, C4-2 and MR49F cells stimulated with the synthetic androgen R1881.
In Vivo
VPC-14449 (100 mg/kg; i.p. twice daily for 4 weeks) reduces tumor volume and abolishes PSA production with no decrease in body weight over a total duration 4 weeks in LNCaP xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nude mice (Harlan Sprague-Dawley; 25-31 g; 6-8 weeks) were subcutaneously inoculated with LNCaP cells and castrated Dosage: 100 mg/kg Administration: I.p. twice daily for 4 weeks Result: Suppressed LNCaP tumor volume and blocked serum PSA production.
Form:Solid
IC50& Target:IC50: 0.34 μM (AR-DBD)
规格
规格或纯度
≥98%
英文名称
VPC-14449
生化机理
VPC-14449 是雄激素受体 DNA 结合域（AR-DBD）的强效选择性抑制剂，对全长人 AR 的 IC 50 为 0.34 μM。VPC-14449 可降低全长 AR 以及 AR 变体与染色质相互作用的能力。
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥98%
名称和识别符
分子类型
小分子
Smiles
BrC1=CN(C2=CSC(N3CCOCC3)=N2)C(Br)=N1
分子量
394.09
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 125 mg/mL (317.19 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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