计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC 50 of 2.35 μM.
In Vitro
At both human and rat receptors, the Cis regioisomer of VU0155041 is similar in potency (798±58 nM at human mGluR4 and 693±140 nM at rat mGluR4). Conversely, the concentration-response curve for the Trans regioisomer (VU0155040) does not plateau at the maximum concentration tested. Fold-shift experiments at 30 μM of VU0155041 also shows that the Cis regioisomer is more effective at this concentration on both human and rat mGluR4. VU0155041, induces concentration-dependent shifts in the baseline when examined in fold shift experiments using the thallium flux assay. VU0155041 induces a response that reaches approximately 45% of the maximal glutamate response. VU0155041is a partial agonist of mGluR4 that activates the receptor by interacting with a site that is distinct from the glutamate binding site. VU0155041 exhibitsselectivity for mGluR4 relative to 67 different targets and does not affect the function of striatal NMDA receptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
VU0155041 is soluble in an aqueous vehicle and intracerebroventricular administration of 31 to 316 nM of VU0155041 dose-dependently decreases haloperidol-induced catalepsy and reserpine-induced akinesia in rats. VU0155041, at doses of 31 and 92 nmol, is also able to significantly decrease the cataleptic effects of haloperidol, and the effects of the compound are still present 30 min after infusion. Icv infusion of a 316 nmol dose of VU0155041 also results in a significant reversal of akinesia . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:mGluR4
规格
规格或纯度
≥98%
英文名称
(1R,2S)-VU0155041
生化机理
(1R,2S)-VU0155041是VU0155041的顺反异构体，是一种部分mGluR4激动剂，EC50为2.35 μM。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激动剂
纯度
≥98%
名称和识别符
EC号
119-554-0
分子类型
小分子
分子量
316.18
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 50 mg/mL (158.14 mM; Need ultrasonic)
安全和危险性（GHS）
信号词
警告
危险声明
H302: 吞食有害
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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