WH-10417-099 is a CRBN-type PROTAC multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). WH-10417-099 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) PI3Kγ ligand 1 , the E3 ubiquitin ligase ligand (blue part) Thalidomide 4-fluoride and the PROTAC linker (black part) Amino-PEG5-C2-acid. The E3 ligase ligand and linker can form a conjugate Pomalidomide 4'-PEG5-acid.