Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
1.Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. (2023) In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. JOURNAL OF FISH DISEASES, 46 (9):(977-986). [PMID:37294673][10.1111/jfd.13818]
2.Wei Liu, Xiao Chen, Chen Yang, Zequn Lin, Xinfeng Huang, Zhen Zhang, Jianjun Liu. (2025) Preventive effects of xanthohumol in APP/PS1 mice based on multi-omics atlas. BRAIN RESEARCH BULLETIN, [PMID:40132750][10.1016/j.brainresbull.2025.111316]
3.Liu Wei, Chen Xiao, Zhao Jing, Yang Chen, Huang Guanqin, Zhang Zhen, Liu Jianjun. (2024) Protective signature of xanthohumol on cognitive function of APP/PS1 mice: a urine metabolomics approach by age. Frontiers in Pharmacology, [PMID:39114364][10.3389/fphar.2024.1423060]
4.Yan Gao, Zilin Song, Wenxin Gan, Xue Zou, Yaning Bai, Xiuli Zhao, Dawei Chen, Mingxi Qiao. (2025) Selective and iron-independent ferroptosis in cancer cells induced by manipulation of mitochondrial fatty acid oxidation. BIOMATERIALS, [PMID:40112511][10.1016/j.biomaterials.2025.123259]
5.Han Ning, Li Jie, Li Yangyang, Zhao Feiei, Wang Jun, Ye Peiyu, Zeng Zhenling. (2024) Xanthohumol ameliorates dextran sodium sulfate-induced colitis in mice by inhibiting of NF-κB signaling pathways and modulating intestinal microbiota. EUROPEAN JOURNAL OF NUTRITION, 64 (1):(1-13). [PMID:39576384][10.1007/s00394-024-03525-5]
6.Aiguo Huang, Yanqin Wei, Jialong Huang, Songlin Luo, Tingyu Wei, Jing Guo, Fali Zhang, Yinghui Wang. (2025) Effects of Natural Ingredient Xanthohumol on the Intestinal Microbiota, Metabolic Profiles and Disease Resistance to Streptococcus agalactiae in Tilapia Oreochromis niloticus. Microorganisms, 13 (7):(1699). [PMID:40732208][10.3390/microorganisms13071699]
7.Wen Yan, Ying Huang, Yanjie Zhou, Qingfang Xie, Wanbin Huang, Yuexiu Lei, Zheman Xiao. (2026) Xanthohumol alleviates central sensitization in migraine via PPARα-mediated activation of the AMPK pathway and suppression of neuroinflammation. PHYTOMEDICINE, [PMID:41539101][10.1016/j.phymed.2026.157816]
G2631079
危险品化学品经营许可证（带存储）