计算溶液所需的质量、体积或浓度。
XRD-0394 is a potent and orally active dual ATM and DNA-PKcs inhibitor with IC 50 s of 0.39 nM and 0.89 nM, respectively. XRD-0394 shows selectivity over other PIKK and PI3K family members. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro.