计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells.
In Vitro
Xylopine (3.5 μM-14 μM; 24-48 hours) displays potent cytotoxicity in a time- and does-depenpent manner. Xylopine (72 h) has cytotoxic activity, with IC50 values ranging from 6.4 to 26.6 μM in eight different cancer cell lines (MCF7, HCT116, HepG2, SCC-9, HSC-3, HL-60, K-562, and B16-F10). Xylopine (3.5 μM-14 μM; 24-48 hours) causes cell cycle block at the phase G2/M, which is followed by internucleosomal DNA fragmentation. Xylopine (3.5 μM-14 μM; 24-48 hours) significantly increases the early and late apoptosis, induces mitochondrial depolarization, and increases caspase-3 activation. Xylopine also causes an increase in the production of reactive oxygen/nitrogen species (ROS/RNS), including hydrogen peroxide and nitric oxide, but not superoxide anion, and reduces glutathione levels are decreased in Xylopine-treated HCT116 cells.\nHCT116 cells3.5 μM, 7 μM, and 14 μM\n24 hours, 48 hours\nInduced G2/M phase arrest.\nHCT116 cells3.5 μM, 7 μM, and 14 μM\n24 hours, 48 hours\nSignificantly increased the early and late apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 cells Concentration: 3.5 μM, 7 μM, and 14 μM Incubation Time: 24 hours, 48 hours Result: Displayed potent cytotoxicity in HCT116 cells. Cell Cycle AnalysisCell Line: HCT116 cells Concentration: 3.5 μM, 7 μM, and 14 μM Incubation Time: 24 hours, 48 hours Result: Induced G2/M phase arrest. Apoptosis AnalysisCell Line: HCT116 cells Concentration: 3.5 μM, 7 μM, and 14 μM Incubation Time: 24 hours, 48 hours Result: Significantly increased the early and late apoptosis.
Form:Solid
规格
别名
赛洛平
规格或纯度
≥98%
英文名称
Xylopine
生化机理
木犀草素是一种卟吩生物碱，对癌细胞具有细胞毒性。木犀草素可诱导氧化应激，导致 G2/M 细胞周期停滞和癌细胞凋亡。
储存条件
2-8°C储存,避光,干燥
运输条件
低温运输
纯度
≥98%
名称和识别符
分子类型
小分子
Smiles
COC1=CC2=C(C=C1)C3=C4[C@@H](C2)NCCC4=CC5=C3OCO5
Isomeric SMILES
COC1=CC2=C(C=C1)C3=C4[C@@H](C2)NCCC4=CC5=C3OCO5
PubChem CID
分子量
295.33
技术文档
高级数据
关联靶点（人）
HT-1080
(3966 活性数据)
SK-MEL-2
(46422 活性数据)
ZR-75-1
(953 活性数据)
A-431
(6446 活性数据)
KB
(17409 活性数据)
关联靶点（其它种属）
Plasmodium falciparum (966862 活性数据)
P388 (20296 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
分子量
295.300 g/mol
XLogP3
2.800
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
4
可旋转键计数Rotatable Bond Count
1
精确质量Exact Mass
295.121 Da
单同位素质量Monoisotopic Mass
295.121 Da
拓扑极表面积Topological Polar Surface Area
39.700 Ų
重原子数Heavy Atom Count
22
形式电荷Formal Charge
0
复杂度Complexity
431.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
1
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）