| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Z408773-1ml |
1ml |
现货  |
|
| 英文别名 | OM-1563 | Zinc, bis[1-(hydroxy-κO)-2(1H)-pyridinethionato-κS2]-, (T-4)- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Zinc Pyrithione |
| 生化机理 | 吡啶硫酮锌（OM-1563）是一种抗真菌和抗菌剂，可通过阻断质子泵来破坏膜运输。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激活剂 |
| 作用机制 | K 激活程序 v7.1；K 激活程序 v7.2；K 激活程序 v7.4；K 激活程序 v7.5 |
| 产品介绍 |
Information Zinc Pyrithione Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential. In vivo Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50)\u2009= 8.27\u2009μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed. cell lines： Concentrations： Incubation Time： Powder Purity:≥97% |
| Canonical SMILES | O1N2C=CC=CC2=[SH][Zn]13ON4C=CC=CC4=[SH]3 |
|---|---|
| 分子量 | 317.7 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 100 mg/mL (153.64 mM); |
|---|
| Concentration | 9-11（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
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