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精氨酸-甘氨酸-天冬氨酸-丝氨酸

纤连蛋白抑制剂
规格或纯度: ≥95%(HPLC)
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
A101721-2mg
 2mg 现货 Stock Image
A101721-5mg
 5mg 现货 Stock Image
A101721-25mg
 25mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
main product photo

基本描述

别名 RGDS|L-精氨酰甘氨酰-L-alpha-天冬氨酰-L-丝氨酸
英文别名 Arg-gly-asp-ser|91037-65-9|Rgds peptide|Fibronectin tetrapeptide|Arginyl-glycyl-aspartyl-serine|AC6UDA2MFC|CHEMBL265628|(3S)-3-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutano
规格或纯度 ≥95%(HPLC)
英文名称 Arg-Gly-Asp-Ser
生化机理 在纤连蛋白，纤维蛋白原α和von Willebrand因子上发现保守的四肽序列Arg-Gly-Asp-Ser（RGDS）。与细胞表面的整合素结合。抑制\ xa0凝血酶诱导的血小板与纤连蛋白，纤维蛋白原αa的结合
储存温度 -20°C储存
运输条件 超低温冰袋运输
备注 需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Arg-Gly-Asp-Ser.It is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.It has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFβ1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages.A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding.

Arg-Gly-Asp-Ser.It is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.It has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFβ1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages.
A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding.

名称和标识符

IUPAC Name (3S)-3-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid
INCHI InChI=1S/C15H27N7O8/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19)/t7-,8-,9-/m0/s1
InChi Key NNRFRJQMBSBXGO-CIUDSAMLSA-N
Canonical SMILES C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)O)N)CN=C(N)N
Isomeric SMILES C(C[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O)N)CN=C(N)N
WGK Germany 3
PubChem CID 107775
分子量 433.42

化学和物理性质

溶解性 Soluble in water (1 mg/ml), yielding a clear, colorless solution.
密度 1.65

安全和危险性（GHS）

WGK Germany 3
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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参考文献

1. Zhao S et al..  (2022)  Sirtuin 1 Induces Choroidal Neovascularization and Triggers Age-Related Macular Degeneration by Promoting LCN2 through SOX9 Deacetylation..  Oxid Med Cell Longev,  2022  ():  (1671438).  [PMID:35720180]
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