C2205416计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™,分析标准品 级 提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 68 篇同行评审文献引用。
概述
Docetaxel (Standard) 是 Docetaxel 的分析标准品。本产品用于研究及分析应用。 Docetaxel (D107320) 是一种微管解聚 (microtubule depolymerization) 抑制剂，其 IC50 值为 0.2 μM。Docetaxel 是紫杉醇的半合成类似物，能减弱 bcl-2 和 bcl-xL 基因表达的影响。Docetaxel 阻滞 G2/M 细胞周期，导致细胞凋亡 (apoptosis)。Docetaxel 具有抗肿瘤活性。
Docetaxel (Standard) is the analytical standard for Docetaxel. This product is used for research and analysis applications. Docetaxel (D107320) is a microtubule depolymerization inhibitor with an IC50 value of 0.2 μ M. Docetaxel is a semi synthetic analog of paclitaxel that can attenuate the effects of Bcl-2 and Bcl xL gene expression. Docetaxel blocks the G2/M cell cycle, leading to apoptosis. Docetaxel has anti-tumor activity.
规格
别名
多西他赛
英文别名
Docetaxel [INN] | D07866 | NSC 759850 | Lead di(acetate) | NCGC00242509-01 | DOCETAXEL MYLAN | Ethanol, 2,2'-iminodi-, 3,5-diiodo-4-oxo-1(4H)-pyridineacetate (salt) | KS-1452 | NCGC00181306-01 | DB12492 | Docetaxel anhydrous | Docetaxol | EmDOC | Q-100074
规格或纯度
Moligand™, 分析标准品, ≥99%
英文名称
Docetaxel
生化机理
Docetaxel is an anticancer agent of paclitaxel, which is associated with paclitaxel. It binds and stabilizes the β - tubulin subunit of microtubules, preventing the depolymerization of the mitotic spindle that leads to cell cycle arrest and apoptosis
储存条件
2-8°C储存,避光
运输条件
低温运输
纯度
≥99%
名称和识别符
PubChem SID
EC号
601-339-2
分子类型
小分子
IUPAC Name
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
INCHI
1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
InChi Key
ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Smiles
CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
Isomeric SMILES
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
分子量
807.88
Reaxy-Rn
24720578
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24720578&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 脂质和脂质样分子 |
| 类（Class) | 异戊烯醇脂质 |
| 亚类（Subclass） | 二萜类化合物 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 紫杉烷及其衍生物 |
| 其他上位类（Alternative Parents） | 苯甲酸酯 三羧酸及其衍生物 苯甲酰衍生物 脂肪酸酯 单糖 叔醇 氨基甲酸酯 仲醇 氧杂环丁烷 羧酸酯 环状醇及其衍生物 酮类 有机碳酸及其衍生物 氧环化合物 多元醇 二烷基醚 碳氢化合物衍生物 有机光子化合物 有机氧化物 有机氮化合物 |
| 分子骨架（Molecular Framework) | 芳香族杂多环化合物 |
| 取代基（Substituents） | 羟基苯甲酸酯 - 芳香族杂多环化合物 - 苯基化合物 - 苯甲酸酯 - 苯甲酸或衍生物 - 苯甲酰 - 脲酸酯 - 碳酸衍生物 - 羰基 - 羧酸衍生物 - 羧酸酰胺 - 环醇 - 二烷基醚 - 乙醚 - 脂肪酸酯 - 脂肪酰基 - 烃衍生物 - 酮 - 单环苯基基团 - 单糖 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机杂环化合物 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 氧杂环 - 氧杂环丁烷 - 多醇 - 醛基 - 紫杉二萜 - 三烷基醇 - 三羧酸或其衍生物 |
| 描述（Description） | 该化合物属于紫杉烷及其衍生物类有机化合物。这类二萜类化合物以紫杉烷骨架或其衍生物为基础结构。在植物化学领域，紫杉烷骨架存在多种衍生物：2(3→20)-阿贝紫杉烷、3,11-环紫杉烷、11(15→1),11(10→9)-阿贝紫杉烷、3,8-甾基紫杉烷及11(15→1)-阿贝紫杉烷等。近期还发现了更复杂的骨架结构，包括紫杉烷衍生的[3.3.3]丙环烷环系。 |
| 外部描述符（External Descriptors） | tetracyclic diterpenoid |
三维结构
交互式化学结构模型
关联靶点（人）
TUBB
Tclin
微管蛋白β链(Tubulin beta chain)
(0 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
GABRA1
Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
AVPR2
Tclin
Vasopressin V2 receptor
(2912 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
AGTR1
Tclin
Type-1 angiotensin II receptor
(5176 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
HTR3A
Tclin
Serotonin 3a (5-HT3a) receptor
(3366 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
GRIN1
Tclin
Glutamate (NMDA) receptor subunit zeta 1
(122 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
CACNA1C
Tclin
Voltage-gated L-type calcium channel alpha-1C subunit
(766 活性数据)
PDE3A
Tclin
Phosphodiesterase 3A
(3309 活性数据)
SLC29A1
Tclin
Equilibrative nucleoside transporter 1
(1711 活性数据)
ADRA2B
Tclin
Alpha-2b adrenergic receptor
(4412 活性数据)
ADRA2C
Tclin
Alpha-2c adrenergic receptor
(4876 活性数据)
CHRM3
Tclin
Muscarinic acetylcholine receptor M3
(7750 活性数据)
HTR2B
Tclin
Serotonin 2b (5-HT2b) receptor
(10323 活性数据)
TBXA2R
Tclin
Thromboxane A2 receptor
(5717 活性数据)
ADORA2A
Tclin
Adenosine A2a receptor
(16305 活性数据)
ADORA3
Tchem
Adenosine A3 receptor
(15931 活性数据)
BDKRB2
Tclin
Bradykinin B2 receptor
(3970 活性数据)
HRH3
Tclin
Histamine H3 receptor
(10389 活性数据)
CHRNA4
Tclin
Neuronal acetylcholine receptor protein alpha-4 subunit
(1265 活性数据)
MC3R
Tchem
Melanocortin receptor 3
(5659 活性数据)
关联靶点（其它种属）
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Pde4d
Phosphodiesterase 4D (4 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
Vero (26788 活性数据)
4T1 (1737 活性数据)
Plasma (328 活性数据)
TUBB2B
Tubulin (2175 活性数据)
Liver microsome (341 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
密度
1.37
敏感性
对光敏感
熔点
186-191°C
分子量
807.900 g/mol
XLogP3
1.600
氢键供体数Hydrogen Bond Donor Count
5
氢键受体数Hydrogen Bond Acceptor Count
14
可旋转键计数Rotatable Bond Count
13
精确质量Exact Mass
807.347 Da
单同位素质量Monoisotopic Mass
807.347 Da
拓扑极表面积Topological Polar Surface Area
224.000 Ų
重原子数Heavy Atom Count
58
形式电荷Formal Charge
0
复杂度Complexity
1660.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
11
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
信号词
危险
危险声明
H319: 引起严重眼睛刺激
H341: 怀疑引起遗传缺陷
H351: 怀疑引起遗传缺陷
H360: 可能损害生育力或未出生的孩子
H361: 怀疑破坏生育力或未出生的孩子
H362: 可能对母乳喂养的孩子造成伤害
H372: 通过长时间或反复暴露对器官造成损害
预防措施声明
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。
P263: 避免在怀孕期间/哺乳期间接触。
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P281: 根据需要使用个人防护设备。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P405: 密闭存放
P501: 将内容物/容器处理到。。。
P203: 使用前，获取、阅读并遵守所有安全说明。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P318: 如果暴露或担心，请就医。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
RTECS
DA4172750
个人防护装备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
技术文档和文章
紫杉醇（Paclitaxel）
目录： 技术文章
Paclitaxel
目录： 技术文章
此产品的引用文献
引用文献
| 1. Wei Pei, Yuqing Li, Yixian Wu, Yuan Wu, Ling Cai, Shaozhuo Wang, Shoulin Wang, Jin Chen. (2023) A Tumoricidal Lipoprotein Complex Electrostatically Stabilized on Mesoporous Silica as Nanotherapeutics and Nanoadjuvant for Potentiating Immunotherapy of Triple Negative Breast Cancer. ADVANCED FUNCTIONAL MATERIALS, [10.1002/adfm.202308117] |
| 2. Shuncheng Yao, Shaobo Wang, Minjia Zheng, Zhuo Wang, Zhirong Liu, Zhong Lin Wang, Linlin Li. (2023) Implantable, Biodegradable, and Wireless Triboelectric Devices for Cancer Therapy Through Disrupting Microtubule and Actins Dynamics. ADVANCED MATERIALS, [PMID:37392034] [10.1002/adma.202303962] |
| 3. Zhuang Yu, Wang Yuxiao, Li Ning, Meng Haitao, Li Zhiyu, Luo Jianguang, Qiu Zhixia. (2023) Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 48 (4): (363-376). [PMID:37344636] [10.1007/s13318-023-00834-8] |
| 4. Jiawei Li, Chunmei Fan, Zhongyang Lv, Ziying Sun, Jie Han, Maochun Wang, Huiming Jiang, Kuoyang Sun, Guihua Tan, Hu Guo, Anlong Liu, Heng Sun, Xingquan Xu, Rui Wu, Wenjin Yan, Qing Jiang, Shiro Ikegawa, Xiao Chen, Dongquan Shi. (2023) Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration. Theranostics, [PMID:37351173] [10.7150/thno.85077] |
| 5. Rengui Xu, Honglian Guo, Xiuli Chen, Jiarong Xu, Yusheng Gong, Peng Cao, Chunyu Wei, Fei Xiao, Di Wu, Wei Chen, Lin Wang, Zheng Wang. (2023) Smart hydrothermally responsive microneedle for topical tumor treatment. JOURNAL OF CONTROLLED RELEASE, [PMID:37182803] [10.1016/j.jconrel.2023.05.008] |
| 6. Qinhui Ren, Yufu Ma, Fuhua Wei, Lan Qin, Hongliang Chen, Zhao Liang, Siyuan Wang. (2023) Preparation of Zr-MOFs for the adsorption of doxycycline hydrochloride from wastewater. Green Processing and Synthesis, 12 (1): [10.1515/gps-2022-8127] |
| 7. Tan Hu, Yang Xu, Gang Xu. (2023) Dipeptide-polysaccharides hydrogels through co-assembly. FOOD CHEMISTRY, [PMID:37141751] [10.1016/j.foodchem.2023.136272] |
| 8. Fang Fang, Shaohua Zhang, Chaofan Chen, Xueying Wang, Chuannan Luo, Qin Wei. (2023) A fluorescent nanoprobe based on N/S co-doped carbon dots coupled with molecularly imprinted polymers for the detection of curcumin. OPTICAL MATERIALS, [10.1016/j.optmat.2023.113800] |
| 9. Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang. (2023) Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel. International Journal of Nanomedicine, [PMID:32982230] [10.2147/IJN.S267177] |
| 10. Tong Le, Zhou ZeYang, Wang Gang, Wu Chao. (2022) A self-microemulsion enhances oral absorption of docetaxel by inhibiting P-glycoprotein and CYP metabolism. Drug Delivery and Translational Research, 13 (4): (983-993). [PMID:36515864] [10.1007/s13346-022-01255-x] |
| 11. Li Huang, Huaqiang Fang, Teng Zhang, Binbin Hu, Shichen Liu, Fanzhen Lv, Zhaoxia Zeng, Huijie Liu, Weimin Zhou, Xiaolei Wang. (2022) Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment. Bioactive Materials, [PMID:36514389] [10.1016/j.bioactmat.2022.11.015] |
| 12. Ruifeng Wu, Zhiqiang Zhang, Baohua Wang, Ge Chen, Yaozhong Zhang, Haowen Deng, Zilong Tang, Junjie Mao, Lei Wang. (2022) Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles. Drug Design Development and Therapy, [PMID:32606595] [10.2147/DDDT.S246574] |
| 13. Dongsheng Fu, Jinhui You, Ruijie Guo, Jie Zhang, Qiang Li, Jing Wen, Huifang Wang, Hong Yan. (2022) Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release. ChemistrySelect, 7 (30): (e202200670). [10.1002/slct.202200670] |
| 14. Hongming Liu, Qin Zhou, Yongfu Lian. (2022) Polymethyl(1–Butyric acidyl)silane–Assisted Dispersion and Density Gradient Ultracentrifugation Separation of Single–Walled Carbon Nanotubes. Nanomaterials, 12 (12): (2094). [PMID:35745430] [10.3390/nano12122094] |
| 15. Lingling Xu, Chuan Zhou, Fan Wang, Huiqin Liu, Guangyuan Dong, Siyi Zhang, Tao Liu. (2022) Functional drug carriers formed by RGD-modified β-CD-HPG for the delivery of docetaxel for targeted inhibition of nasopharyngeal carcinoma cells. RSC Advances, 12 (28): (18004-18011). [PMID:35765336] [10.1039/D2RA02301F] |
| 16. Wei Pei, Ling Cai, Xing Gong, Li Zhang, Jiarong Zhang, Ping Zhu, Huijun Jiang, Chao Wang, Shoulin Wang, Jin Chen. (2022) Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy. Materials Today Bio, [PMID:35607417] [10.1016/j.mtbio.2022.100272] |
| 17. Yingying Zhang, Hongxia Duan, Heming Zhao, Lingling Qi, Yanhong Liu, Zheao Zhang, Chao Liu, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang. (2022) Development and Evaluation of a PSMA-Targeted Nanosystem Co-Packaging Docetaxel and Androgen Receptor siRNA for Castration-Resistant Prostate Cancer Treatment. Pharmaceutics, 14 (5): (964). [PMID:35631549] [10.3390/pharmaceutics14050964] |
| 18. Jia Gao, Li Chen, Yongsheng Yan, Jian Lu, Wendong Xing, Jiangdong Dai, Minjia Meng, Yilin Wu. (2021) Dot-matrix-initiated molecularly imprinted nanocomposite membranes for selective recognition: a high-efficiency separation system with an anti-oil fouling layer. Environmental Science-Nano, 8 (10): (2932-2949). [10.1039/D1EN00296A] |
| 19. Yingying Chai, Yuefei Wang, Bingqi Li, Wei Qi, Rongxin Su, Zhimin He. (2021) Microfluidic Synthesis of Lignin/Chitosan Nanoparticles for the pH-Responsive Delivery of Anticancer Drugs. LANGMUIR, [PMID:34078082] [10.1021/acs.langmuir.1c00778] |
| 20. Ruiqi Xu, Mengnan Zeng, Yuanyuan Wu, Shengchao Wang, Beibei Zhang, Jingke Zhang, Yuxuan Kan, Benke Li, Bing Cao, Xiaoke Zheng, Weisheng Feng. (2021) Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling. OncoTargets and Therapy, [PMID:34093025] [10.2147/OTT.S308371] |
| 21. Wenjia Wang, Xiaoqin Zhang, Zhiqian Li, Dayi Pan, Hongyan Zhu, Zhongwei Gu, Jie Chen, Hu Zhang, Qiyong Gong, Kui Luo. (2021) Dendronized hyaluronic acid-docetaxel conjugate as a stimuli-responsive nano-agent for breast cancer therapy. CARBOHYDRATE POLYMERS, [PMID:34119134] [10.1016/j.carbpol.2021.118160] |
| 22. Zhirong Zhu, Guiliang Tang, Jiajun Yan. (2020) MicroRNA‑122 regulates docetaxel resistance of prostate cancer cells by regulating PKM2. Experimental and Therapeutic Medicine, 20 (6): (1-1). [PMID:33178345] [10.3892/etm.2020.9377] |
| 23. Hongyan Zhang, Shuang Dong, Sheng Zhang, Yufen Li, Ji Li, Yinghui Dai, Dongkai Wang. (2020) pH-responsive lipid polymer hybrid nanoparticles (LPHNs) based on poly (β-amino ester) as a promising candidate to resist breast cancers. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [10.1016/j.jddst.2020.102102] |
| 24. Yuan He, Zhuyifan Ye, Xinyang Liu, Zhengjie Wei, Fen Qiu, Hai-Feng Li, Ying Zheng, Defang Ouyang. (2020) Can machine learning predict drug nanocrystals?. JOURNAL OF CONTROLLED RELEASE, [PMID:32234511] [10.1016/j.jconrel.2020.03.043] |
| 25. Tian'e Chen, Liangxing Tu, Ge Wang, Na Qi, Wei Wu, Wei Zhang, Jianfang Feng. (2020) Multi-functional chitosan polymeric micelles as oral paclitaxel delivery systems for enhanced bioavailability and anti-tumor efficacy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:32018019] [10.1016/j.ijpharm.2020.119105] |
| 26. Yao Yang, Zhengwei Huang, Jinyuan Li, Ziran Mo, Ying Huang, Cheng Ma, Wenhao Wang, Xin Pan, Chuanbin Wu. (2019) PLGA Porous Microspheres Dry Powders for Codelivery of Afatinib-Loaded Solid Lipid Nanoparticles and Paclitaxel: Novel Therapy for EGFR Tyrosine Kinase Inhibitors Resistant Nonsmall Cell Lung Cancer. Advanced Healthcare Materials, 8 (23): (1900965). [PMID:31664795] [10.1002/adhm.201900965] |
| 27. Jiafeng Gao, Kai Fan, Yipeng Jin, Linna Zhao, Qian Wang, Yinian Tang, Huihao Xu, Zhongjie Liu, Shuaiyu Wang, Jiahao Lin, Degui Lin. (2019) PEGylated lipid bilayer coated mesoporous silica nanoparticles co-delivery of paclitaxel and curcumin leads to increased tumor site drug accumulation and reduced tumor burden. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:31518679] [10.1016/j.ejps.2019.105070] |
| 28. Wei Fu, Zhiming Hong, Xujun You, Jing Din, Baishu Chen, Beibei Zhao, Gengyan Yuan, Qixin Li. (2019) Enhancement of anticancer activity of docetaxel by combination with Fuzheng Yiliu decoction in a mouse model of castration-resistant prostate cancer. BIOMEDICINE & PHARMACOTHERAPY, [PMID:31545228] [10.1016/j.biopha.2019.109374] |
| 29. Tao Liu, Jingzhen Li, Xidong Wu, Siyi Zhang, Zhongming Lu, Guanxue Li, Junzheng Li, Shaohua Chen. (2019) Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma. DRUG DELIVERY, [PMID:31340676] [10.1080/10717544.2019.1642421] |
| 30. Ting Zhao, Shiwei Qin, linna Peng, Pan Li, Tao Feng, Jingyuan Wan, Pei Yuan, Liangke Zhang. (2019) Novel hyaluronic acid-modified temperature-sensitive nanoparticles for synergistic chemo-photothermal therapy. CARBOHYDRATE POLYMERS, [PMID:30925992] [10.1016/j.carbpol.2019.03.043] |
| 31. Ruoning Wang, Mengmeng Yang, Guoyuan Li, Xin Wang, Zhenhai Zhang, Hongzhi Qiao, Jun Chen, Zhipeng Chen, Xiaobin Cui, Junsong Li. (2018) Paclitaxel-betulinic acid hybrid nanosuspensions for enhanced anti-breast cancer activity. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:30469048] [10.1016/j.colsurfb.2018.11.029] |
| 32. Lei Xu, Shuo Wu, Xiaoqiu Zhou. (2018) Bioinspired nanocarriers for an effective chemotherapy of hepatocellular carcinoma. JOURNAL OF BIOMATERIALS APPLICATIONS, [PMID:29699442] [10.1177/0885328218772721] |
| 33. Ling-Yuan Guo, Shu-Zhen Yan, Qiang Li, Qiao Xu, Xi Lin, Shan-Shan Qi, Shu-Qin Yu, Shuang-Lin Chen. (2017) Poly(lactic-co-glycolic) acid nanoparticles improve oral bioavailability of hypocrellin A in rat. RSC Advances, 7 (67): (42073-42082). [10.1039/C7RA04748G] |
| 34. Lin Yu, Xiaofeng Wu, Min Chen, Huarong Huang, Yan He, Huaqian Wang, Dongli Li, Zhiyun Du, Kun Zhang, Susan Goodin, Xi Zheng. (2017) The Effects and Mechanism of YK-4-279 in Combination with Docetaxel on Prostate Cancer. International Journal of Medical Sciences, [PMID:28553168] [10.7150/ijms.18382] |
| 35. Enhui Zhang, Ronge Xing, Song Liu, Kecheng Li, Yukun Qin, Huahua Yu, Pengcheng Li. (2017) Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:28389400] [10.1016/j.ijbiomac.2017.03.195] |
| 36. Zejun Xu, Yi Zhang, Qian Hu, Qiao Tang, Jiake Xu, Jianping Wu, Thomas Brett Kirk, Dong Ma, Wei Xue. (2016) Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery. Materials Science & Engineering C-Materials for Biological Applications, [PMID:27987795] [10.1016/j.msec.2016.11.005] |
| 37. Xiaoyan Zhou, Qianqian Zheng, Changyong Wang, Jiake Xu, Jian-Ping Wu, Thomas Brett Kirk, Dong Ma, Wei Xue. (2016) Star-Shaped Amphiphilic Hyperbranched Polyglycerol Conjugated with Dendritic Poly(l-lysine) for the Codelivery of Docetaxel and MMP-9 siRNA in Cancer Therapy. ACS Applied Materials & Interfaces, [PMID:27153187] [10.1021/acsami.6b01611] |
| 38. De-Hong Yu, Ya-Rong Liu, Xin Luan, Hai-Jun Liu, Yun-Ge Gao, Hao Wu, Chao Fang, Hong-Zhuan Chen. (2015) IF7-Conjugated Nanoparticles Target Annexin 1 of Tumor Vasculature against P-gp Mediated Multidrug Resistance. BIOCONJUGATE CHEMISTRY, [PMID:26076081] [10.1021/acs.bioconjchem.5b00283] |
| 39. Chang-Wei Li, Hua-Jin Dong, Cheng-Bin Cui. (2015) The Synthesis and Antitumor Activity of Twelve Galloyl Glucosides. MOLECULES, 20 (2): (2034-2060). [PMID:25633333] [10.3390/molecules20022034] |
| 40. Chao Yang, Lina Han, Fei Ma, Lin Zhou, Jiahong Zhou, Shaohua Wei, Guiqin Huang, Jian Shen, Fuyou Li. (2013) Synthesis of Calcium Phosphate Nanoparticle-Based Docetaxel Delivery System and its In Vitro Anticancer Activity. International Journal of Applied Ceramic Technology, 12 (2): (300-305). [10.1111/ijac.12159] |
| 41. Jiang Xiaoqian, Qu Aihua, Xu Xinxin, Kuang Hua, Liu Liqiang, Xu Chuanlai. (2024) A gold-based multiplex immunochromatographic sensor for detecting paclitaxel, methotrexate, and 5-fluorouracil in clinical samples. Nano Research, [10.1007/s12274-024-6649-7] |
| 42. Yaowei Zhu, Ruijie Tang, Jun Zhao, Changlong Jiang, Lingfei Li, Bianhua Liu. (2025) Design and application of metal-organic framework based chemo-fluorescent sensor for selective sensing of the full spectrum of tetracyclines in complex samples. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2025.160281] |
| 43. Yuanxin Pian, Yan Hao, Yuxin Guo, Shiqi Wu, Saijiao Tang, Jiaqi Li, Xinya Lu, Xiaoya Sun, Zhaowen Tan, Tianyu Zhu, Yuxiang Tang, Defeng Xu, Hang Hu. (2025) Exploration of using α-crocin for drug encapsulation and delivery. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [10.1016/j.jddst.2025.106716] |
| 44. Xiaojing Zhang, Yansong Chen, Jingwei Tang, Chen Chen, Yanfeng Sun, Hao Zhang, Mengxiang Qiao, Gongsheng Jin, Xianfu Liu. (2024) GSH-activable heterotrimeric nano-prodrug for precise synergistic therapy of TNBC. BIOMEDICINE & PHARMACOTHERAPY, [PMID:38460372] [10.1016/j.biopha.2024.116375] |
| 45. Ying Li, Xiaoying Liu, Jie Wang, Si Li. (2024) High-generation tetracyclines shifted microbial community composition and induced the emergence of antibiotic resistant bacteria in soil. JOURNAL OF HAZARDOUS MATERIALS, [PMID:39259998] [10.1016/j.jhazmat.2024.135757] |
| 46. Han Zhang, Fang Fang, Jiangle Yi, Yuanling Sun, Xueying Wang. (2025) Molecularly imprinted polymer coupled with zinc-doped carbon quantum dots as a fluorescent probe for the determination of doxorubicin hydrochloride. NEW JOURNAL OF CHEMISTRY, 49 (8): (3200-3206). [10.1039/D4NJ05142D] |
| 47. Longxin Lin, Yaling Zheng, Caixia Huang, Lanlan Cai, Hua Zhang, Wen Xu, Xiaoying Wang, Wei Xu. (2024) Oral and tumor-targeting mixed micelles based on pegylated biotin and chitosan-based conjugate for breast cancer treatment. EUROPEAN POLYMER JOURNAL, [10.1016/j.eurpolymj.2024.113592] |
| 48. Jia Yu, Qian Liu, Yuejiao Zhang, Lingfeng Xu, Xiaohua Chen, Feng He, Mian Zhang, Hongxu Yang, Shibing Yu, Xin Liu, Yaoping Wu, Meiqing Wang. (2024) Stress causes lipid droplet accumulation in chondrocytes by impairing microtubules. OSTEOARTHRITIS AND CARTILAGE, [PMID:39730095] [10.1016/j.joca.2024.08.015] |
| 49. Xueyan Hou, Jingya Zhao, Jingjing Xu, Yuxin Wang, Hongyan Xu, Qinghe Gao, Yalin Guan, Yiqiu Xiong, Sisi He, Yongli Shi. (2024) Tumor Microenvironment-Responsive Ternary Nanosystem for Enhanced Antitumor and Antimetastasis Efficacy Against Breast Cancer. ACS Applied Nano Materials, [10.1021/acsanm.4c06164] |
| 50. Hui-Qin Liu, Xi-Dong Wu, Xue-Wen Fang, Yun-Song An, Meng Xia, Xiao-Hua Luo, Jun-Zheng Li, Guan-Hai Wang, Tao Liu. (2024) Tumor-Targeted Magnetic Micelles for Magnetic Resonance Imaging, Drug Delivery, and Overcoming Multidrug Resistance. ACS Omega, [PMID:39713686] [10.1021/acsomega.4c07132] |
| 51. Liyun Ma, Zhi Li, Yiyi Shi, Yuchen Xie, Ming Jiang, Xu Yu, Li Xu. (2024) Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon-Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous Detection and Removal of Oxytetracycline. Advanced Science, [PMID:39651852] [10.1002/advs.202410306] |
| 52. Jingmei Zhou, Min Lin, Yan Mo, Ruiyue Dang, Jin Zhou, Chengmin Li, Xin Deng, Alaa Aldeen Alsaeedi, Yingqi Zhao, Juan Huang, Lijuan Ma, Xueping Feng, Yong Liu, Yunyun Wang. (2025) Formation and evaluation of docetaxel and triptolide polymer micelles for anti-cancer activity. Nanomedicine, [PMID:40736067] [10.1080/17435889.2025.2535281] |
| 53. Ye Zhou, Simeng Wang, Jiahua Guo, Chenghao Li, Mengjun Sui, Zekun Zeng, Hui Dang, Qingqing Gu, Jian Zhu, Yangyang Cheng, Peng Hou. (2024) Harnessing transcription factor-driven ROS for synergistic multimodal lung cancer treatment. JOURNAL OF CONTROLLED RELEASE, [PMID:39182692] [10.1016/j.jconrel.2024.08.035] |
| 54. Guobo Chen, Jing Ping, Jun Du, Linghao Zhao, Yuhao Li, Hui Liu. (2024) Glutathione and acid dual-responsive bismuth-based nanosensitizer for chemo-mediated cancer sonodynamic therapy. Biomedical Materials, 19 (4): (045035). [PMID:38857606] [10.1088/1748-605X/ad565c] |
| 55. Yuan Lin, Chuangnan Li, Kaijie Cen, Jucai Xu, Jing Chen. (2024) Fabrication, characterization, and in vitro biological evaluation of glycyrrhetinic acid ligand-functionalized proliposomes encapsulated docetaxel for treatment of hepatocellular carcinoma. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [10.1016/j.colsurfa.2024.135802] |
| 56. Ru Li, Yimei Ma, Anqi He, Yamin Pu, Xuanting Wan, Hongbao Sun, Ningyu Wang, Min Luo, Guan Wang, Yong Xia. (2025) Fasting enhances the efficacy of Sorafenib in breast cancer via mitophagy mediated ROS-driven p53 pathway. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:39864757] [10.1016/j.freeradbiomed.2025.01.047] |
| 57. Yang Wang, Dianpeng Li, Min He, Gang Wang, Shulin Zhao. (2025) Remodeling the Tumor Microenvironment via Metal-Phenolic Network-Coated Poly(lactic acid-co-glycolic acid) Nanoparticles for Inducing Multimodal Combination Therapy in Non-Small Cell Lung Cancer. ACS Applied Bio Materials, [PMID:40556407] [10.1021/acsabm.5c00634] |
| 58. Chen Biqing, Gao Jiayin, Sun Haizhu, Zhao Yinghan, Liu Yan, Lv Xinpeng, Qiu Xiaohong, Li Yang. (2025) Application of surface-enhanced Raman scattering combined with artificial intelligence for multiplex detection of chemotherapeutic agents used in solid tumors. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:41324706] [10.1007/s00216-025-06241-z] |
| 59. You Xujun, Li Honghan, Li Qixin, Zhang Qing, Cao Yiguo, Fu Wei, Wang Bin. (2025) Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, [PMID:40237800] [10.1007/s00210-025-04122-x] |
| 60. Kong Linghui, Hu Song, Zhao Ying, Huang Yan, Xiang Xiaobing, Yu Yang, Mao Xiaochun, Xie Kangjie, Zhu Xiaoyan, Xu Pingbo. (2025) Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage. BREAST CANCER RESEARCH, 27 (1): (1-19). [PMID:40270028] [10.1186/s13058-025-02011-y] |
| 61. Sai-Nan Qin, Yi-Xue Zhang, Yi-Jie Cao, Ting Wan, Yi-Yang Zhou, Shan-Shan Su, Yu-Qiong Guo, Jian-Jun Sun, Kalle Salminen. (2026) A self-assembled electrochemical aptasensor for one-step rapid detection of cisplatin in blood via aptamer conformational change. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2026.116962] |
| 62. Yangyang Song, Xue Tan, Kai Yu, Yue Wang, Jixue Wang. (2026) Tumor-responsive PEGylated mesoporous nanoparticles achieve enhanced chemotherapy and reduced toxicity in prostate cancer. International Journal of Pharmaceutics-X, [PMID:41675220] [10.1016/j.ijpx.2026.100492] |
| 63. Xinying Wang, Xianlu Zhang, Zixuan Jiao, Shipeng Ning, Hanping Wang, Hui Liu, Lifen He, Haonan Li, Mingzhong Li, Kaiyuan Wang, Zhonggui He, You Pan. (2026) An Exosome-Inspired Docetaxel Prodrug Nanoplatform for Potent STING Activation and Synergistic Chemoimmunotherapy. Asian Journal of Pharmaceutical Sciences, [10.1016/j.ajps.2026.101139] |
| 64. Tong Zhao, Luying Xu, Wenjie Huang, Cong Wang, Huanhuan Wang, Mengyue Du, Chang Yao, Yanlei Xu. (2026) Chrysophanol Attenuates Breast Cancer Angiogenesis Through Blocking VEGFA/VEGFR2/ERK Activation via Inhibiting ACE2 Ubiquitination. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:41905439] [10.1016/j.ejphar.2026.178810] |
| 65. Ying He, Nengbin Wan, Hongwu Deng, Yi Zhang, Qiang Liu, Li Li, Hao Liu, Xiao He, Qing Zhu. (2026) cRGD-modified, pH-sensitive liposomes for co-delivery of docetaxel and ABCG2 siRNA enhance therapeutic efficacy in triple-negative breast cancer. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:41865608] [10.1016/j.colsurfb.2026.115616] |
| 66. Wang Weilin, Hu Qiaoying, Wu Chunyan, Ding Jiayue, Zhu Chuanxiu, Wen Jiayao, Li Yingchao, Yang Menghan, Wang Yujie, Sun Deqing, Zhai Guangxi, Zhang Yanan. (2026) A ferroptosis-based intelligent nanoplatform with chemo-sonodynamic therapy carrying oxygen for improving tumor suppression and antitumor immunity. JOURNAL OF NANOBIOTECHNOLOGY, [PMID:42104396] [10.1186/s12951-026-04409-y] |
| 67. Song Hu, Linghui Kong, Mo Chen, Cheng Teng, Ying Zhao, Xiaohong Yuan, Shunv Cai, Xiaoyan Zhu, Pingbo Xu. (2026) Inhibition of the cGAS-STING pathway mitigates liver injury induced by docetaxel-carboplatin neoadjuvant chemotherapy via autophagy promotion. ACTA BIOCHIMICA ET BIOPHYSICA SINICA, [PMID:42212620] [10.3724/abbs.2026094] |
| 68. Jiayi Yao, Jiaqi Wang, Peipei Bu, Kexin Liu, Mingyang Zhao, Jingkai Gu, Xiangjun Meng. (2026) The impact of the DiI fluorescent probe on the in vivo fate of paclitaxel-loaded methoxy polyethylene glycol-block-poly (D, L-lactide) micelles. DRUG METABOLISM AND DISPOSITION, [10.1016/j.dmd.2026.100372] |
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）