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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| I348993-100mg |
100mg |
期货  |
|
| 英文别名 | indinavir|150378-17-9|Crixivan|Compound J|MK-639|Indinavir anhydrous|MK639|CHEBI:44032|(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D |
|---|---|
| 规格或纯度 | 98% |
| 英文名称 | Indinavir |
| 储存温度 | 室温 |
| 运输条件 | 常规运输 |
| 产品介绍 |
Indinavir 是HIV-1蛋白酶抑制剂的新型羟氨基戊烷酰胺类的成员。 Indinavir is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. |
| pKa值 | pKa: 5.19 (Predicted) |
|---|---|
| Ki Data | Human immunodeficiency virus type 1 protease: Ki= 0.07 nM (Human immunodeficiency virus 1); Human rhinovirus A protease: Ki= 3.3 nM (Human rhinovirus sp.); Cytochrome P450 3A4: Ki= 480 nM (human) |
| IC50 | Human immunodefIC₅₀ncy virus type 1 protease: IC₅₀= 0.36 nM (Human immunodefIC₅₀ncy virus 1); Human immunodefIC₅₀ncy virus 2: IC₅₀= 4 nM; Human T-lymphotropIC₅₀irus 1: IC₅₀= 22 nM; Human immunodefIC₅₀ncy virus 1: IC₅₀≤10 nM |
| IUPAC Name | (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide |
|---|---|
| INCHI | InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1 |
| InChi Key | CBVCZFGXHXORBI-PXQQMZJSSA-N |
| Canonical SMILES | CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5 |
| Isomeric SMILES | CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5 |
| PubChem CID | 5362440 |
| 分子量 | 613.81 |
| 溶解性 | Soluble in water (0.02 mg/mL).(unbuffered) |
|---|---|
| 密度 | 1.25 g/cm3 |
| 折光率 | n20D1.64 |
| 比旋光度 | α20/D +24.1°, c = 0.01 in chloroform |
| 沸点 | 877.89° C at 760 mmHg |
| 熔点 | 153-154° C |
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